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Cites:

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Information Journal Paper

Title

The Effect of Safranal on Th1/Th2 Cytokine Balance

Author(s)

 Feyzi Reza | BOSKABADY MOHAMMAD HOSSEIN | Seyedeh Masoumeh Seyed hosseini Tamijani | RAFATPANAH HOUSHANG | Rezaei Seyed Abdolrahim | Issue Writer Certificate 

Pages

  263-273

Abstract

 Background: Several biological and medical benefits of Saffron, Crocus sativus (Iridaceae), have been demonstrated. However, mechanisms of actions for purified constituents are greatly unknown. Objective: To examine the effects of Safranal, a main constituent of Saffron stigma, on Cell Viability and Cytokine profile of peripheral blood mononuclear cells (PBMC) were examined. Methods: Effects of Safranal at 0. 1, 0. 5 and 1 mM concentrations were evaluated on Cell Viability and production of interleukin 4 (IL-4), IL-10 and interferon-γ (IFN-γ ) from non-stimulated and phytohemagglutinin (PHA) stimulated PBMCs, compared to 0. 1 mM dexamethasone and saline. Results: In stimulated cells, different concentrations of Safranal caused significant decrease of lymphocytes viability (p<0. 001 for all concentrations). All concentrations of Safranal inhibited IFN-γ and IL-10 secretion in stimulated cells (p<0. 01). In addition, high concentration of Safranal significantly decreased Cell Viability of non-stimulated PBMCs (p<0. 001). The effect of 1 mM Safranal on IL-4 secretion was less than dexamethasone (p<0. 05). Safranal showed a stimulatory effect on IFN-γ secretion in non-stimulated cells. The IFN-γ /IL-4 ratio at the presence of two higher Safranal concentrations both in non-stimulated and stimulated cells were significantly higher than those of control and PHA stimulated groups, respectively (p<0. 05). Conclusion: The IFN-γ /IL-4 ratio increases in the presence of Safranal which indicates an effect on Th1/Th2 balance. Therefore, Safranal may have therapeutic effects in inflammatory diseases associated with Th1/Th2 imbalance.

Cites

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    • Cite

    APA: Copy

    Feyzi, Reza, BOSKABADY, MOHAMMAD HOSSEIN, Seyedeh Masoumeh, Seyed hosseini Tamijani, RAFATPANAH, HOUSHANG, & Rezaei, Seyed Abdolrahim. (2016). The Effect of Safranal on Th1/Th2 Cytokine Balance. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 13(4), 263-273. SID. https://sid.ir/paper/296930/en

    Vancouver: Copy

    Feyzi Reza, BOSKABADY MOHAMMAD HOSSEIN, Seyedeh Masoumeh Seyed hosseini Tamijani, RAFATPANAH HOUSHANG, Rezaei Seyed Abdolrahim. The Effect of Safranal on Th1/Th2 Cytokine Balance. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2016;13(4):263-273. Available from: https://sid.ir/paper/296930/en

    IEEE: Copy

    Reza Feyzi, MOHAMMAD HOSSEIN BOSKABADY, Seyed hosseini Tamijani Seyedeh Masoumeh, HOUSHANG RAFATPANAH, and Seyed Abdolrahim Rezaei, “The Effect of Safranal on Th1/Th2 Cytokine Balance,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 13, no. 4, pp. 263–273, 2016, [Online]. Available: https://sid.ir/paper/296930/en

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