Food Security Research Center, Health Research Institute, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, iran

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GOLMOGHADDAM HOSSEIN; FARJADIAN SHIRIN; KHOSROPANAH SHAHDAD; DEHGHANI POOYAN; DOROUDCHI MEHRNOOSH

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Journal Paper

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Journal: Iranian Journal of Immunology Year:2018 | Volume:15 | Issue:3 Page(s): 197-206

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Information Journal Paper

Title

Food Security Research Center, Health Research Institute, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, iran

Author(s)

Keywords

Atherosclerosis

Blood Pressure

HLA-DRB1

Hyperlipidemia

Inflammation

Abstract

Background: Human leukocyte antigen (HLA) complex is a gene family involved in antigen presentation associated with protection or susceptibility to inflammatory, infectious and autoimmune diseases. Atherosclerosis is a chronic inflammatory disease in which HLA molecules play a role in the initiation and development of the disease through presentation of self or foreign antigens to T cells. Objective: To investigate the association of HLA-DRB1 alleles with Atherosclerosis in a sample of southwestern Iranians. Methods: We performed an analytical cross-sectional study involving 96 patients with Atherosclerosis and 72 controls. HLA-DRB1 genotyping was performed by PCR-SSP method. Results: We observed a significantly lower frequency of DRB1*01 in patients with coronary artery Atherosclerosis than in controls (4. 68% vs. 13. 1, P=0. 0052, OR=3. 09, CI 95%: 1. 35-7. 05). However, this allele showed a positive association with high Blood Pressure (P=0. 009) in patients. Furthermore, DRB1*16 allele was associated with Hyperlipidemia (P=0. 008) in patients. Conclusion: Our results demonstrated that DRB1*01 may be a protective allele against Atherosclerosis in individuals who live in southwest of Iran. The mechanism of this protection needs further investigation.

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APA: Copy

GOLMOGHADDAM, HOSSEIN, FARJADIAN, SHIRIN, KHOSROPANAH, SHAHDAD, DEHGHANI, POOYAN, & DOROUDCHI, MEHRNOOSH. (2018). Food Security Research Center, Health Research Institute, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, iran. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 15(3), 197-206. SID. https://sid.ir/paper/296953/en

Vancouver: Copy

GOLMOGHADDAM HOSSEIN, FARJADIAN SHIRIN, KHOSROPANAH SHAHDAD, DEHGHANI POOYAN, DOROUDCHI MEHRNOOSH. Food Security Research Center, Health Research Institute, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, iran. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2018;15(3):197-206. Available from: https://sid.ir/paper/296953/en

IEEE: Copy

HOSSEIN GOLMOGHADDAM, SHIRIN FARJADIAN, SHAHDAD KHOSROPANAH, POOYAN DEHGHANI, and MEHRNOOSH DOROUDCHI, “Food Security Research Center, Health Research Institute, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, iran,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 15, no. 3, pp. 197–206, 2018, [Online]. Available: https://sid.ir/paper/296953/en

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