SHORT PAPER: Association of Interleukin-1 Gene Polymorphism with Risk of Gastric and Colorectal Cancers in an Iranian Population

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Abbasian Mohammad Hadi; ABBASI BAHAREH; Ansarinejad Nafiseh; motevalizadeh Ardekani Ali; SAMIZADEH ESMAEIL; GOHARI MOGHADDAM KATAYOUN; HASHEMI MAHMOOD REZA

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Journal: Iranian Journal of Immunology Year:2018 | Volume:15 | Issue:4 Page(s): 321-328

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Title

SHORT PAPER: Association of Interleukin-1 Gene Polymorphism with Risk of Gastric and Colorectal Cancers in an Iranian Population

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Keywords

Colorectal Cancer

Genetic Polymorphisms

Inflammations

Interleukin 1 receptor antagonist

Abstract

Background: Chronic inflammation is associated with neoplasms and several types of cancer. Therefore, polymorphisms in the inflammation-related genes could modify the cancer susceptibility. Objective: To investigate the associations between IL-1RN VNTR and rs419598 polymorphisms in IL-1 receptor antagonist (IL-1ra) and Colorectal Cancer (CRC) and gastric cancer (GC) in an Iranian population. Methods: In this study, 126 cancer cases (91 CRC and 35 GC) and 97 healthy controls were included. Genotyping of IL-1RN VNTR and rs419598 was performed by PCR amplification and PCR-RFLP, respectively. Logistic regression was applied to identify the independent risk factors for colorectal and gastric cancers by computing the odds ratio (OR) and 95% confidence intervals (95% CI). All statistical analyses were performed using the SPSS statistical software. Results: There were significant differences between cancer groups and control group concerning the frequency of A1/A2 genotypes in IL-1RN VNTR polymorphism. The carrier status of IL-1RN* 2 allele was associated with increased risk of CRC (p = 0. 0003; OR = 0. 02; 95% CI: 0. 491-0. 85) and GC (p = 0. 0006; OR = 0. 106; 95% CI: 0. 321-0. 035). Also, the homozygous ILRN *2/*2 genotype was associated with increased risk of gastric cancer (p = 0. 04; OR = 0. 133; 95% CI: 0. 020-0. 908). There was no association between different alleles of rs419598 and CRC and GC. Conclusion: This study demonstrates an association between the carrier status of IL-1RN* 2 and CRC and GC in an Iranian population.

Cites

The Role of Dihydropyrimidine Dehydrogenase and Thymidylate Synthase Polymorphisms in Fluoropyrimidine-Based Cancer Chemotherapy in an Iranian Population

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APA: Copy

Abbasian, Mohammad Hadi, ABBASI, BAHAREH, Ansarinejad, Nafiseh, motevalizadeh Ardekani, Ali, SAMIZADEH, ESMAEIL, GOHARI MOGHADDAM, KATAYOUN, & HASHEMI, MAHMOOD REZA. (2018). SHORT PAPER: Association of Interleukin-1 Gene Polymorphism with Risk of Gastric and Colorectal Cancers in an Iranian Population. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 15(4), 321-328. SID. https://sid.ir/paper/296958/en

Vancouver: Copy

Abbasian Mohammad Hadi, ABBASI BAHAREH, Ansarinejad Nafiseh, motevalizadeh Ardekani Ali, SAMIZADEH ESMAEIL, GOHARI MOGHADDAM KATAYOUN, HASHEMI MAHMOOD REZA. SHORT PAPER: Association of Interleukin-1 Gene Polymorphism with Risk of Gastric and Colorectal Cancers in an Iranian Population. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2018;15(4):321-328. Available from: https://sid.ir/paper/296958/en

IEEE: Copy

Mohammad Hadi Abbasian, BAHAREH ABBASI, Nafiseh Ansarinejad, Ali motevalizadeh Ardekani, ESMAEIL SAMIZADEH, KATAYOUN GOHARI MOGHADDAM, and MAHMOOD REZA HASHEMI, “SHORT PAPER: Association of Interleukin-1 Gene Polymorphism with Risk of Gastric and Colorectal Cancers in an Iranian Population,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 15, no. 4, pp. 321–328, 2018, [Online]. Available: https://sid.ir/paper/296958/en

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