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Information Journal Paper

Title

Decreased Level of IL-37 Correlates Negatively with Inflammatory Cytokines in Cerebrospinal Fluid of Patients with Neuro-Behcet’ s Disease

Pages

  299-310

Abstract

 Background: Behç et's disease (BD) is a systemic inflammatory disease with a chronic, relapsing-remitting course of unknown etiology. Neuro-Behcet’ s disease (NBD) induce serious CNS complications and are known to be the main cause of long-term morbidity and mortality. IL‐ 37 is a natural suppressor of innate inflammation which its role in NBD has not been fully understood. Objective: To determine the expression of IL-37 in cerebrospinal fluid (CSF) and its relationship with other Inflammatory Cytokines. Methods: Level of IL-37, IL-6, IL-17, IL-21, TSLP and TGF-β were measured in CSF of 22 patients with NBD and 12 non-inflammatory neurological disease (NIND) and 10 headache attributed to Behç et's disease (HaBD) by enzyme‐ linked immunosorbent assay (ELISA). In addition, IL-37 mRNA relative expression was detected by quantitative reverse transcriptase‐ polymerase chain reaction (RT‐ PCR). Results: CSF level and mRNA expression of IL‐ 37 were elevated in NBD patients compared to those in NIND and HaBD patients. Levels of IL-6, IL-17, IL-21 and TSLP were found to be increased in NBD patients and were inversely associated with IL-37 level. Moreover, TGF-β level in CSF of NBD patients was positively correlated with IL-37 levels. IL-37 increased significantly after treatment and in remission group, but TGF-β was only increased in treatment group. Conclusion: IL‐ 37 expression increased in NBD patients, and correlated with disease activity. Our data conclude that IL-37 could be a disease marker in NBD, however it requires further studies.

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    APA: Copy

    Dhifallah, Imene Ben, BORHANI HAGHIGHI, AFSHIN, Hamzaoui, Agnes, & Hamzaoui, Kamel. (2019). Decreased Level of IL-37 Correlates Negatively with Inflammatory Cytokines in Cerebrospinal Fluid of Patients with Neuro-Behcet’ s Disease. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 16(4), 299-310. SID. https://sid.ir/paper/296980/en

    Vancouver: Copy

    Dhifallah Imene Ben, BORHANI HAGHIGHI AFSHIN, Hamzaoui Agnes, Hamzaoui Kamel. Decreased Level of IL-37 Correlates Negatively with Inflammatory Cytokines in Cerebrospinal Fluid of Patients with Neuro-Behcet’ s Disease. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2019;16(4):299-310. Available from: https://sid.ir/paper/296980/en

    IEEE: Copy

    Imene Ben Dhifallah, AFSHIN BORHANI HAGHIGHI, Agnes Hamzaoui, and Kamel Hamzaoui, “Decreased Level of IL-37 Correlates Negatively with Inflammatory Cytokines in Cerebrospinal Fluid of Patients with Neuro-Behcet’ s Disease,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 16, no. 4, pp. 299–310, 2019, [Online]. Available: https://sid.ir/paper/296980/en

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