IN VITRO ACTIVITY OF MEFLOQUINE AND ITS ENANTIOMERS AGAINST PLASMODIUM FALCIPARUM

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SOURI E.; NATEGHPOUR M.; FARSAM H.; HAMEDI Y.; AMANLOU M.; KAJI Z.

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT) Year:2002 | Volume:1 | Issue:1 Page(s): 17-19

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Information Journal Paper

Title

IN VITRO ACTIVITY OF MEFLOQUINE AND ITS ENANTIOMERS AGAINST PLASMODIUM FALCIPARUM

Author(s)

Keywords

MEFLOQUINE

ENANTIOMER

ANTIPARASITE

PLASMODIUM FALCIPARUM

Abstract

The in vitro activity of rac-MEFLOQUINE hydrochloride and its pure ENANTIOMERs was tested against a chloroquine-resistant (PF.IBS2) strain of PLASMODIUM FALCIPARUM. The parasite isolated from Iranian patients was cultured in vitro by the candle jar method described by Tranger and Jensen and was exposed to the racemic MEFLOQUINE or its ENANTIOMERs over the concentration range of 10-9 to 10-4M. Neither rac-MEFLOQUINE nor the ENANTIOMERs showed antiparasitic activity at 10-9 M. The (+)-MEFLOQUINE was more potent than the (-)-MEFLOQUINE and the racemate by IC50 equal to 1.17 µM in comparison to 4.09 µM.

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APA: Copy

SOURI, E., NATEGHPOUR, M., FARSAM, H., HAMEDI, Y., AMANLOU, M., & KAJI, Z.. (2002). IN VITRO ACTIVITY OF MEFLOQUINE AND ITS ENANTIOMERS AGAINST PLASMODIUM FALCIPARUM . IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 1(1), 17-19. SID. https://sid.ir/paper/297029/en

Vancouver: Copy

SOURI E., NATEGHPOUR M., FARSAM H., HAMEDI Y., AMANLOU M., KAJI Z.. IN VITRO ACTIVITY OF MEFLOQUINE AND ITS ENANTIOMERS AGAINST PLASMODIUM FALCIPARUM . IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2002;1(1):17-19. Available from: https://sid.ir/paper/297029/en

IEEE: Copy

E. SOURI, M. NATEGHPOUR, H. FARSAM, Y. HAMEDI, M. AMANLOU, and Z. KAJI, “IN VITRO ACTIVITY OF MEFLOQUINE AND ITS ENANTIOMERS AGAINST PLASMODIUM FALCIPARUM ,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 1, no. 1, pp. 17–19, 2002, [Online]. Available: https://sid.ir/paper/297029/en

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