A HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY FOR THE DETERMINATION OF LOSARTAN IN PLASMA

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JALALIZADEH H.; SOURI E.; FARSAM H.; ANSARI M.

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT) Year:2003 | Volume:2 | Issue:1 Page(s): 18-21

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Information Journal Paper

Title

A HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY FOR THE DETERMINATION OF LOSARTAN IN PLASMA

Author(s)

JALALIZADEH H. | SOURI E. | FARSAM H. | ANSARI M. | Issue Writer Certificate

Keywords

LOSARTAN

PLASMA

EXTRACTION

HPLC ANALYSIS

Abstract

A rapid and sensitive HPLC method was developed for determination of LOSARTAN in PLASMA. LOSARTAN was extracted from PLASMA by a two-step EXTRACTION procedure using chloroform as extracting solvent in acidic medium. HPLC ANALYSIS was performed on a cyano reversed-phase column using phosphate buffer (pH 4.3), acetonitrile (750:250, v/v) as mobile phase with a flow rate of 0.9 mL/min. Sodium diclofenac was selected as internal standard. Excellent linearity between the peak area ratios and LOSARTAN concentrations over the range of 2-200 ng/mL of PLASMA was observed. The limit of determination with UV detection at 225 nm, with a CV < 5% was 2 ng/mL in 500 µL of PLASMA sample. The assay was rapid, safe and reliable for use in pharmacokinetic studies of LOSARTAN in human being.

Cites

DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF LOSARTAN IN PHARMACEUTICAL FORMULATIONS

References

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APA: Copy

JALALIZADEH, H., SOURI, E., FARSAM, H., & ANSARI, M.. (2003). A HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY FOR THE DETERMINATION OF LOSARTAN IN PLASMA. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 2(1), 18-21. SID. https://sid.ir/paper/297050/en

Vancouver: Copy

JALALIZADEH H., SOURI E., FARSAM H., ANSARI M.. A HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY FOR THE DETERMINATION OF LOSARTAN IN PLASMA. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2003;2(1):18-21. Available from: https://sid.ir/paper/297050/en

IEEE: Copy

H. JALALIZADEH, E. SOURI, H. FARSAM, and M. ANSARI, “A HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY FOR THE DETERMINATION OF LOSARTAN IN PLASMA,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 2, no. 1, pp. 18–21, 2003, [Online]. Available: https://sid.ir/paper/297050/en

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