THE PHARMACOKINETICS OF RAFOXANIDE FOLLOWING SINGLE DOSE INTRAVENOUS AND ORAL ADMINISTRATION IN GOATS

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PAL S.; GHANDRA DEBNATH SH.; KUMAR DAS SH.; KUMAR GHAKRABORTY A.; KUMAR MANDAL T.

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Journal: IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT) Year:2004 | Volume:3 | Issue:1 Page(s): 26-29

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Title

THE PHARMACOKINETICS OF RAFOXANIDE FOLLOWING SINGLE DOSE INTRAVENOUS AND ORAL ADMINISTRATION IN GOATS

Author(s)

Keywords

RAFOXANIDE

PHARMACOKINETICS

GOATS

ORAL

INTRAVENOUS

Abstract

The study was conducted to determine the plasma concentrations and pharmacokinetic parameters of RAFOXANIDE after a single INTRAVENOUS (10 mg/kg) and ORAL (22.5 mg/kg) administrations in black Bengal female GOATS. Maximum (87.63±11.71 µg/ml) and minimum (1.8±0.24 µg/ml) plasma concentrations of RAFOXANIDE were recorded at 0.08 and 12 h respectively after Lv. administration. The elimination half life (t1.2) , total body clearance (GIB)and volume of distribution (Vdarea)values were 2.89±0.26 h, 0.05 ± 0.002 mg/h and 0.19±0.02 Lkg respectively. An adequate plasma level of RAFOXANIDE (14.63±2.12 mg/ml) was detected at 1h followed by gradual increase and peak concentration level (30.88±4.30 mg/ml) was recorded at 36 h after ORAL administration. The rate of absorption (Ka), elimination half life (t112 P), total body clearance (GIB) and volume of distribution (Vdarea) values were 0.07±0.009 h-1,138.02± 13.99 h, 0.003±0.0003 L/kg/h, and 0.57±0.06L/kg/h respectively. Plasma protein binding percentages of RAFOXANIDE varied from 81.06 to 92.28 and its association and dissociation constants were 1.26 x 107 ± 0.18 X 107 L/mol and 0.83 x 10-7±0.12 x 10-7mol/L respectively. On conclusion, RAFOXANIDE is slowly absorbed from the gastrointestinal tract, slowly eliminated; highly protein bound and persists for long time in blood of goat.

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APA: Copy

PAL, S., GHANDRA DEBNATH, SH., KUMAR DAS, SH., KUMAR GHAKRABORTY, A., & KUMAR MANDAL, T.. (2004). THE PHARMACOKINETICS OF RAFOXANIDE FOLLOWING SINGLE DOSE INTRAVENOUS AND ORAL ADMINISTRATION IN GOATS. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 3(1), 26-29. SID. https://sid.ir/paper/297052/en

Vancouver: Copy

PAL S., GHANDRA DEBNATH SH., KUMAR DAS SH., KUMAR GHAKRABORTY A., KUMAR MANDAL T.. THE PHARMACOKINETICS OF RAFOXANIDE FOLLOWING SINGLE DOSE INTRAVENOUS AND ORAL ADMINISTRATION IN GOATS. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2004;3(1):26-29. Available from: https://sid.ir/paper/297052/en

IEEE: Copy

S. PAL, SH. GHANDRA DEBNATH, SH. KUMAR DAS, A. KUMAR GHAKRABORTY, and T. KUMAR MANDAL, “THE PHARMACOKINETICS OF RAFOXANIDE FOLLOWING SINGLE DOSE INTRAVENOUS AND ORAL ADMINISTRATION IN GOATS,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 3, no. 1, pp. 26–29, 2004, [Online]. Available: https://sid.ir/paper/297052/en

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