مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

SUCCINIC ACID MONOETHYL ESTER AND METFORMIN REGULATES CARBOHYDRATE METABOLIC ENZYMES AND IMPROVES GLYCEMIC CONTROL IN STREPTOZOTOCIN-NICOTINAMIDE INDUCED TYPE 2 DIABETIC RATS

Pages

  132-137

Abstract

 Objective: Succnic acid mono ethyl ester (EMS) was recently proposed as an insulinotropic agent for the treatment of non-insulin dependent DIABETES MELLITUS. In the present study the effect of EMS and METFORMIN on the activities of carbohydrate metabolic enzymes in streptozotocin–nicotinamide induced type 2 diabeteic model was investigated. Methods: EMS were injected intraperitonially at doses 2, 4, mol/g body weight (bw) respectively for 30 days, after which blood and 8 μ hemoglobin, glycosylated hemoglobin, plasma glucose and insulin, hexokinase, glucose-6-phosphatase, fructose-1, 6-bisphosphatase, glucose-6-phosphate dehydrogenase in liver and glycogen in liver and muscle were assayed. Results: Glucose, glycosylated hemoglobin, glucose-6-phosphatase and fructose-1,6-bis phosphatase were significantly increased and insulin, hemoglobin, hexokinase, glucose-6-phosphate dehydrogenase and glycogen were significantly decreased in diabetic rats. The enzyme activities were restored to the near normal levels in diabetic rats treated with EMS and METFORMIN. Conclusion: Our result suggest that non glucidic nutrient- EMS may act as a potent antidiabetic and insulinotropic agent by restoring the above biochemi-cal alterations in streptozotocin -nicotinamide induced type 2 diabetes.

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    Cite

    APA: Copy

    PARI, L., & SARAVANAN, R.. (2005). SUCCINIC ACID MONOETHYL ESTER AND METFORMIN REGULATES CARBOHYDRATE METABOLIC ENZYMES AND IMPROVES GLYCEMIC CONTROL IN STREPTOZOTOCIN-NICOTINAMIDE INDUCED TYPE 2 DIABETIC RATS. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 4(2), 132-137. SID. https://sid.ir/paper/297080/en

    Vancouver: Copy

    PARI L., SARAVANAN R.. SUCCINIC ACID MONOETHYL ESTER AND METFORMIN REGULATES CARBOHYDRATE METABOLIC ENZYMES AND IMPROVES GLYCEMIC CONTROL IN STREPTOZOTOCIN-NICOTINAMIDE INDUCED TYPE 2 DIABETIC RATS. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2005;4(2):132-137. Available from: https://sid.ir/paper/297080/en

    IEEE: Copy

    L. PARI, and R. SARAVANAN, “SUCCINIC ACID MONOETHYL ESTER AND METFORMIN REGULATES CARBOHYDRATE METABOLIC ENZYMES AND IMPROVES GLYCEMIC CONTROL IN STREPTOZOTOCIN-NICOTINAMIDE INDUCED TYPE 2 DIABETIC RATS,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 4, no. 2, pp. 132–137, 2005, [Online]. Available: https://sid.ir/paper/297080/en

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