ALLELE FREQUENCY OF CYP2C19 GENE POLYMORPHISMS IN A HEALTHY IRANIAN POPULATION

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ZAND N.; TAJIK NADER; HOURMAND M.; SALEK MOGHADAM ALI REZA; MILANIAN I.

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Paper Information

Journal: IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT) Year:2005 | Volume:4 | Issue:2 Page(s): 124-128

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Information Journal Paper

Title

ALLELE FREQUENCY OF CYP2C19 GENE POLYMORPHISMS IN A HEALTHY IRANIAN POPULATION

Author(s)

Keywords

CYP2C19

IRANIAN POPULATION

PCR-RFLP

PHARMACOGENETICS

POLYMORPHISM

Abstract

Cytochrome P450 2C19 (CYP2C19) plays an important role in the metabolism and elimination of a wide range of medications. The POLYMORPHISMs of this enzyme give rise to substantial inter-individual and inter-ethnic variability in drug excretion rates and final serum concentrations. For this reason, therapeutic responses and adverse drug reactions may vary from one person to another. In this study we determined genotypes of CYP2C19 in IRANIAN POPULATION to compare allele frequencies with previous findings in other ethnic groups. CYP2C19 (*1/*2/*3) allelic variants were determined in 200 unrelated healthy Iranian volunteers by polymerase chain reaction-restriction fragment length POLYMORPHISM (PCR-RFLP) assays. Six subjects (3%) were homozygous for CYP2C19*2, while 44 individuals (22%) were heterozygous. In the remainder (75%) no CYP2C19*2 was found. In addition, no CYP2C19*3 was detected in the population studied. Based on our data, there was no difference between frequency of CYP2C19 allelic variants in our study and other evaluated Caucasians (p > 0.05).

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APA: Copy

ZAND, N., TAJIK, NADER, HOURMAND, M., SALEK MOGHADAM, ALI REZA, & MILANIAN, I.. (2005). ALLELE FREQUENCY OF CYP2C19 GENE POLYMORPHISMS IN A HEALTHY IRANIAN POPULATION. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 4(2), 124-128. SID. https://sid.ir/paper/297086/en

Vancouver: Copy

ZAND N., TAJIK NADER, HOURMAND M., SALEK MOGHADAM ALI REZA, MILANIAN I.. ALLELE FREQUENCY OF CYP2C19 GENE POLYMORPHISMS IN A HEALTHY IRANIAN POPULATION. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2005;4(2):124-128. Available from: https://sid.ir/paper/297086/en

IEEE: Copy

N. ZAND, NADER TAJIK, M. HOURMAND, ALI REZA SALEK MOGHADAM, and I. MILANIAN, “ALLELE FREQUENCY OF CYP2C19 GENE POLYMORPHISMS IN A HEALTHY IRANIAN POPULATION,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 4, no. 2, pp. 124–128, 2005, [Online]. Available: https://sid.ir/paper/297086/en

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