BENEFICIAL EFFECT OF COENZYME Q10 IN STREPTOZOTOCIN-INDUCED TYPE I DIABETIC RATS

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MODI K.P.; VISHWAKARMA S.L.; GOYAL R.K.; BHATT P.A.

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Journal: IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT) Year:2006 | Volume:5 | Issue:1 Page(s): 61-65

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Title

BENEFICIAL EFFECT OF COENZYME Q10 IN STREPTOZOTOCIN-INDUCED TYPE I DIABETIC RATS

Author(s)

MODI K.P. | VISHWAKARMA S.L. | GOYAL R.K. | BHATT P.A. | Issue Writer Certificate

Keywords

COENZYME Q10

STREPTOZOTOCIN

DIABETES

Abstract

The present investigation was undertaken to study the beneficial effects of COENZYME Q10 in STREPTOZOTOCIN (STZ) -induced type I diabetic rats. STZ-diabetes produced a significant increase in fasting glucose levels that was associated with decrease in serum insulin levels. STZ also produced hypercholesteloremia hypertriglyceredemia, increase in lipid peroxidation and decrease in high density lipoprotein (HDL) levels. COENZYME Q10 was also found to decrease significantly AUCglucose and no significant change in AUC insulin values in STZ-diabetic rats. Treatment with COENZYME Q10 also caused decreased in serum cholesterol, serum triglyceride levels and an increase in HDL levels. COENZYME Q10 treatment also reduced lipid peroxidation in diabetic rats. The elevated blood pressure in diabetic rats was also lowered. Our data suggest that COENZYME Q10 has beneficial effects in DIABETES induced complications.

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APA: Copy

MODI, K.P., VISHWAKARMA, S.L., GOYAL, R.K., & BHATT, P.A.. (2006). BENEFICIAL EFFECT OF COENZYME Q10 IN STREPTOZOTOCIN-INDUCED TYPE I DIABETIC RATS. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 5(1), 61-65. SID. https://sid.ir/paper/297108/en

Vancouver: Copy

MODI K.P., VISHWAKARMA S.L., GOYAL R.K., BHATT P.A.. BENEFICIAL EFFECT OF COENZYME Q10 IN STREPTOZOTOCIN-INDUCED TYPE I DIABETIC RATS. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2006;5(1):61-65. Available from: https://sid.ir/paper/297108/en

IEEE: Copy

K.P. MODI, S.L. VISHWAKARMA, R.K. GOYAL, and P.A. BHATT, “BENEFICIAL EFFECT OF COENZYME Q10 IN STREPTOZOTOCIN-INDUCED TYPE I DIABETIC RATS,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 5, no. 1, pp. 61–65, 2006, [Online]. Available: https://sid.ir/paper/297108/en

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