PHARMACOKINETICS AND DOSAGE REGIMEN OF CEFEPIME FOLLOWING SINGLE DOSE INTRAVENOUS ADMINISTRATION IN CALVES

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PATEL U.D.; BHAVSAR SH.K.; THAKER A.M.

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Journal: IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT) Year:2006 | Volume:5 | Issue:2 Page(s): 127-130

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Title

PHARMACOKINETICS AND DOSAGE REGIMEN OF CEFEPIME FOLLOWING SINGLE DOSE INTRAVENOUS ADMINISTRATION IN CALVES

Author(s)

PATEL U.D. | BHAVSAR SH.K. | THAKER A.M. | Issue Writer Certificate

Keywords

CEFEPIME

CALVES

PHARMACOKINETICS

INTRAVENOUS

Abstract

Pharmacokinetics of CEFEPIME was studied after single dose INTRAVENOUS administration at the dose rate of 5 mg/kg body weight in CALVES. Blood samples were collected from the jugular vein at predetermined time intervals before and after drug administration. Serum was harvested and analyzed for CEFEPIME concentration by reverse-phase high performance liquid chromatography. Following INTRAVENOUS administra-tion, the mean serum CEFEPIME level of 44.93 ± 5.47 mg/mL was observed at 0.033 h (2 minutes). The therapeutically effective concentration of CEFEPIME ( ³ 1.00 mg/mL) was maintained in serum up to 12 h. The distribution half-life (t1/2a) and elimination half-life (t1/2b) were 0.09 ± 0.01 h and 3.70 ± 0.16 h, respectively. The mean values of apparent volume of distribution [Vd(area)] and volume of distribution of drug at steady-state (Vd(ss)) were calculated to be 0.57 ± 0.03 and 0.43 ± 0.03 L/kg, respectively. The mean value of total body clearance (ClB) was 1.81 ± 0.16 mL/min/kg. The average values for area under serum drug concentration-time curve (AUC) and area under first moment of curve (AUMC) were 47.73 ± 4.05 ±g h/mL and 190.3 ± 19.9 ±mg h2/mL. The average value of mean residence time (MRT) was 3.95 ± 0.11 h. A satisfactory INTRAVENOUS dosage regimen would be 4.20 mg/kg body weight as priming dose followed by 3.78 mg/kg repeated at 12 h intervals.

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APA: Copy

PATEL, U.D., BHAVSAR, SH.K., & THAKER, A.M.. (2006). PHARMACOKINETICS AND DOSAGE REGIMEN OF CEFEPIME FOLLOWING SINGLE DOSE INTRAVENOUS ADMINISTRATION IN CALVES. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 5(2), 127-130. SID. https://sid.ir/paper/297114/en

Vancouver: Copy

PATEL U.D., BHAVSAR SH.K., THAKER A.M.. PHARMACOKINETICS AND DOSAGE REGIMEN OF CEFEPIME FOLLOWING SINGLE DOSE INTRAVENOUS ADMINISTRATION IN CALVES. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2006;5(2):127-130. Available from: https://sid.ir/paper/297114/en

IEEE: Copy

U.D. PATEL, SH.K. BHAVSAR, and A.M. THAKER, “PHARMACOKINETICS AND DOSAGE REGIMEN OF CEFEPIME FOLLOWING SINGLE DOSE INTRAVENOUS ADMINISTRATION IN CALVES,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 5, no. 2, pp. 127–130, 2006, [Online]. Available: https://sid.ir/paper/297114/en

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