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Information Journal Paper

Title

SUB-CHRONIC TOXICITY STUDY OF ALFA-CYPERMETHRIN IN RATS

Pages

  163-166

Abstract

 Alfa-cypermethrin (A-CP) a synthetic pyrethroid (type-II) insecticide, dissolved in dimethyl sulfoxide (DMSO-1 mL) was given consecutive daily orally for 60 days at 1/10 LD50 (14.5 mg/kg). The animals were sacrificed on day 61st. Biochemicals, CYTOCHROME P450, b5 contents in liver along with antioxidant status, TISSUE RESIDUAL CONCENTRATION, and BRAIN GABA LEVEL were studied. It increased the serum aminotransami-nase (AST, ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) activities and blood glucose level significantly (p<0.05). It significantly (p<0.05) decreased and increases CYTOCHROME P450 content and b5 content in liver respectively. It increased the malondialdehyde (MDA) level, and decreased the activities of catalase (CAT) and superoxide dismutase (SOD) and glycogen in liver significantly. The py-rethroid was considerable in amount in tissues. The GABA levels in cerebellum and in whole brain without cerebellums were decreased significantly (p<0.05). Therefore repeated daily oral dose toxicity of A-CP at 1/10 LD50 altered biochemical parameters, decreased CYTOCHROME P450 content, antioxidant status, and decreased BRAIN GABA LEVEL.

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    Cite

    APA: Copy

    MANNA, S.K., BHATTACHARYYA, D., KUMAR MANDAL, T., & KUMAR DAS, SH.. (2006). SUB-CHRONIC TOXICITY STUDY OF ALFA-CYPERMETHRIN IN RATS. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 5(2), 163-166. SID. https://sid.ir/paper/297127/en

    Vancouver: Copy

    MANNA S.K., BHATTACHARYYA D., KUMAR MANDAL T., KUMAR DAS SH.. SUB-CHRONIC TOXICITY STUDY OF ALFA-CYPERMETHRIN IN RATS. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2006;5(2):163-166. Available from: https://sid.ir/paper/297127/en

    IEEE: Copy

    S.K. MANNA, D. BHATTACHARYYA, T. KUMAR MANDAL, and SH. KUMAR DAS, “SUB-CHRONIC TOXICITY STUDY OF ALFA-CYPERMETHRIN IN RATS,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 5, no. 2, pp. 163–166, 2006, [Online]. Available: https://sid.ir/paper/297127/en

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