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Information Journal Paper

Title

INFLUENCE OF N-PHTHALOYL GABA ON THE CIRCADIAN RHYTHMS OF LIPID PEROXIDATION AND ANTIOXIDANTS IN WISTAR RATS UNDER CONSTANT LIGHT

Pages

  115-118

Abstract

 N-Phthaloyl GABA was administrated daily (50mg/Kg body weight-i.p) to Wistar rats for 21 days and cir-cadian rhythms of thiobarbituric acid reactive substances (TBARS) and ANTIOXIDANTS such as reduced glu-tathione (GSH), catalase (CAT) and superoxide dismutase (SOD) were studied under CONSTANT LIGHT (LL) conditions. Delayed acrophase of TBARS and advanced acrophase of ANTIOXIDANTS (GSH, CAT and SOD) were found in experimental groups as compared with control rats. LL-exposed rats showed increased mesor of TBARS and decreased mesor of ANTIOXIDANTS. Administrations of GABA reversed all the changes to the near normal. Since GABA is being involved in conveying dark information to clock, exoge-nous administration of P-GABA might reduce the photic information received by the clock. The exact mechanism is still unclear and further research is needed to elucidate the mechanism(s) involved.

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    Cite

    APA: Copy

    SUBASH, S., & SUBRAMANIAN, P.. (2007). INFLUENCE OF N-PHTHALOYL GABA ON THE CIRCADIAN RHYTHMS OF LIPID PEROXIDATION AND ANTIOXIDANTS IN WISTAR RATS UNDER CONSTANT LIGHT. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 6(2), 115-118. SID. https://sid.ir/paper/297152/en

    Vancouver: Copy

    SUBASH S., SUBRAMANIAN P.. INFLUENCE OF N-PHTHALOYL GABA ON THE CIRCADIAN RHYTHMS OF LIPID PEROXIDATION AND ANTIOXIDANTS IN WISTAR RATS UNDER CONSTANT LIGHT. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2007;6(2):115-118. Available from: https://sid.ir/paper/297152/en

    IEEE: Copy

    S. SUBASH, and P. SUBRAMANIAN, “INFLUENCE OF N-PHTHALOYL GABA ON THE CIRCADIAN RHYTHMS OF LIPID PEROXIDATION AND ANTIOXIDANTS IN WISTAR RATS UNDER CONSTANT LIGHT,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 6, no. 2, pp. 115–118, 2007, [Online]. Available: https://sid.ir/paper/297152/en

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