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Information Journal Paper

Title

ELECTRICAL LESION OF SUBSTANTIA NIGRA PARS COMPACTA: AN ALTERNATIVE AND CONVENIENT WAY TO GENERATE THE ANIMAL MODEL OF PARKINSON’S DISEASE

Pages

  53-56

Keywords

6-HYDROXYDOPAMINE (6-OHDA) 
2 
3 
6-TETRAHYDROPYRIDINE (MPTP) 

Abstract

 The unilateral or bilateral lesions of the SUBSTANTIA NIGRA PARS COMPACTA (SNc) by chemical neurotoxins such as 6-hydroxydopamine (6-OHDA) or 1-METHYL-4-PHENYL-1,2,3,6-tetrahydropyridine (MPTP) are main method for generating the PARKINSON'S ANIMAL MODELs. But these neurotoxins are expensive, dangerous, difficult to use and inaccessible conveniently due to the international economical sanctions in Iran. The present study was designed to find a new animal model for Parkinson's disease. Forty eight animals were included in this study and divided into six groups. One group was selected as the control and also two groups as the sham of the SNc lesion. Other groups were subjected to lesion of SNc by 6-OHDA, MPTP and ELECTRICAL LESION. Using histological studies and Murprogo’s method precision, the effectiveness of the ELECTRICAL LESION was compared with that of chemical lesions. Our results showed the same extent of lesion was provided with electrical insult and neurotoxins. Due to the technical convenience, low cost, accessibility and the same potency of electrical- and neurotoxins-induced lesion, this model can be used as an alternative method for creating the Parkinson's models.

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    APA: Copy

    FATHI MOGHADAM, H., & SHAFIEI ARDESTANI, MAHDI. (2008). ELECTRICAL LESION OF SUBSTANTIA NIGRA PARS COMPACTA: AN ALTERNATIVE AND CONVENIENT WAY TO GENERATE THE ANIMAL MODEL OF PARKINSON’S DISEASE. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 7(1), 53-56. SID. https://sid.ir/paper/297172/en

    Vancouver: Copy

    FATHI MOGHADAM H., SHAFIEI ARDESTANI MAHDI. ELECTRICAL LESION OF SUBSTANTIA NIGRA PARS COMPACTA: AN ALTERNATIVE AND CONVENIENT WAY TO GENERATE THE ANIMAL MODEL OF PARKINSON’S DISEASE. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2008;7(1):53-56. Available from: https://sid.ir/paper/297172/en

    IEEE: Copy

    H. FATHI MOGHADAM, and MAHDI SHAFIEI ARDESTANI, “ELECTRICAL LESION OF SUBSTANTIA NIGRA PARS COMPACTA: AN ALTERNATIVE AND CONVENIENT WAY TO GENERATE THE ANIMAL MODEL OF PARKINSON’S DISEASE,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 7, no. 1, pp. 53–56, 2008, [Online]. Available: https://sid.ir/paper/297172/en

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