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Information Journal Paper

Title

IN VITRO LIPID PEROXIDATION INHIBITORY AND NTIMICROBIAL ACTIVITY OF PHYLLANTHUS NIRURI (EUPHORBIACEAE) EXTRACT

Pages

  67-70

Abstract

 The present work was designed to evaluate the in vitro lipid peroxidation inhibitory and antimicrobial activities of the methanol extract of PHYLLANTHUS NIRURI (MEPN) (Family: Euphorbiaceous). Lipid peroxidation as measured by the optical density of the prepared solutions (10-320 μg/ml) and then the percent inhibi-ion was calculated. Ascorbate/FeSO4-induced per oxidation was inhibited by standard antioxidants such s L-ascorbic acid, quercetin and MEPN. Moreover, the percent inhibition of the methanol extract was increased in a concentration-dependent manner. IC50 value for the MEPN, L-ascorbic acid and quercetin or lipid per oxidation was found to be 62.5 mg/ml, 41 mg/ml and 19.75 mg/ml respectively. The ANTIMICROBIAL ACTIVITY of MEPN was determined by disc diffusion method with various gram-positive and gram-negative microorganisms. The MEPN showed strong ANTIMICROBIAL ACTIVITY against Bacillus pummel’s 8241, bacillus cereus, Escherichia Coli 54B and Vibrae Cholera at a concentration of 750 mg/ml/disc. However, its activity against Staphylococcus aureus ML 152 and Vibrae cholera 14035 was less significant. The ntimicrobial activity of the extract was compared with the standard drug, chloramphenicol at a concentra-ion of 10mg/ml/disc. The results obtained in the present investigation clearly suggest that MEPN can be a potential source of natural antioxidant and antimicrobial agent.

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    APA: Copy

    RAJESHWAR, Y., AHMAD, RAYEES, SUNDER, A.S., DEVILAL, J., GUPTA, M., & MAZUMDER, U.K.. (2008). IN VITRO LIPID PEROXIDATION INHIBITORY AND NTIMICROBIAL ACTIVITY OF PHYLLANTHUS NIRURI (EUPHORBIACEAE) EXTRACT. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 7(1), 67-70. SID. https://sid.ir/paper/297177/en

    Vancouver: Copy

    RAJESHWAR Y., AHMAD RAYEES, SUNDER A.S., DEVILAL J., GUPTA M., MAZUMDER U.K.. IN VITRO LIPID PEROXIDATION INHIBITORY AND NTIMICROBIAL ACTIVITY OF PHYLLANTHUS NIRURI (EUPHORBIACEAE) EXTRACT. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2008;7(1):67-70. Available from: https://sid.ir/paper/297177/en

    IEEE: Copy

    Y. RAJESHWAR, RAYEES AHMAD, A.S. SUNDER, J. DEVILAL, M. GUPTA, and U.K. MAZUMDER, “IN VITRO LIPID PEROXIDATION INHIBITORY AND NTIMICROBIAL ACTIVITY OF PHYLLANTHUS NIRURI (EUPHORBIACEAE) EXTRACT,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 7, no. 1, pp. 67–70, 2008, [Online]. Available: https://sid.ir/paper/297177/en

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