PHARMACOKINETICS OF CEFEPIME FOLLOWING INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION IN SHEEP

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PATEL P.N.; PATEL U.D.; BHAVSAR SH.K.; THAKER A.M.

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT) Year:2010 | Volume:9 | Issue:1 Page(s): 7-10

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Title

PHARMACOKINETICS OF CEFEPIME FOLLOWING INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION IN SHEEP

Author(s)

PATEL P.N. | PATEL U.D. | BHAVSAR SH.K. | THAKER A.M. | Issue Writer Certificate

Keywords

PHARMACOKINETICS

CEFEPIME

SHEEP

INTRAVENOUS

INTRAMUSCULAR

Abstract

PHARMACOKINETICS of CEFEPIME was studied following single dose INTRAVENOUS and INTRAMUSCULAR administration at the dose of 20 mg/kg of body weight in SHEEP. Drug concentration in serum was determined using high performance liquid chromatography (HPLC). Following single dose INTRAVENOUS administration, the drug was rapidly distributed (t1/2a: 0.20±0.02 h) and eliminated (t1/2b: 2.54±0.12 h) from the body. The area under curve (AUC0-¥) was 135.50±5.63 mg h/mL. The drug was cleared at the rate of 2.48±0.09 mL/min/kg with mean residence time (MRT) of 2.84±0.13 h. Following IM administration, the drug was rapidly absorbed (Cmax: 26.34±1.44 mg/mL; tmax: 0.75 h) and slowly eliminated (t1/2b: 5.17±0.44 h) from body. The volume of distribution at steady state (Vdss), area under curve (AUC), total body clearance (ClB) and mean residence time (MRT) were 1.11±0.10 L/kg, 140.90±8.67 mg h/mL, 0.15±0.01 mL/min/kg and 6.89±1.0 h, respectively. The bioavailability of CEFEPIME following INTRAMUSCULAR administration was 103±8.0%.

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APA: Copy

PATEL, P.N., PATEL, U.D., BHAVSAR, SH.K., & THAKER, A.M.. (2010). PHARMACOKINETICS OF CEFEPIME FOLLOWING INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION IN SHEEP. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 9(1), 7-10. SID. https://sid.ir/paper/297217/en

Vancouver: Copy

PATEL P.N., PATEL U.D., BHAVSAR SH.K., THAKER A.M.. PHARMACOKINETICS OF CEFEPIME FOLLOWING INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION IN SHEEP. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2010;9(1):7-10. Available from: https://sid.ir/paper/297217/en

IEEE: Copy

P.N. PATEL, U.D. PATEL, SH.K. BHAVSAR, and A.M. THAKER, “PHARMACOKINETICS OF CEFEPIME FOLLOWING INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION IN SHEEP,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 9, no. 1, pp. 7–10, 2010, [Online]. Available: https://sid.ir/paper/297217/en

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