PROTECTIVE EFFECT OF OCIMUM SANCTUM ON DISPOSITION KINETICS OF SULPHADIMIDINE IN LEAD-TREATED COCKEREL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

PRAKASH A.; SINGH P.; VARMA R.; CHOUDHARY G.K.; SAJAN R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT) Year:2010 | Volume:9 | Issue:1 Page(s): 1-5

Download Full-Text

View:

281

Download:

132

Cites:

Information Journal Paper

Title

PROTECTIVE EFFECT OF OCIMUM SANCTUM ON DISPOSITION KINETICS OF SULPHADIMIDINE IN LEAD-TREATED COCKEREL

Author(s)

Keywords

DISPOSITION KINETICS

SULPHADIMIDINE

LEAD

COCKERELS

OSCIMUM SANCTUM

Abstract

This study was carried out to evaluate the protective effect of Ocimum sanctum (tulsi) on LEAD-induced alteration in DISPOSITION KINETICS of SULPHADIMIDINE (SD) in COCKERELS. Twenty-one, four-week male white leghorn (WLH) chicks were randomly divided into groups I, II and III (7 in each) and were fed at dietary with 0 ppm LEAD and no tulsi (group I, Control), 100 ppm LEAD (group II), or 100 ppm LEAD + 100 ppm tulsi (group III). After four weeks, DISPOSITION KINETICS of intravenous single dose administration of SD (50 mg /kg) was determined in each bird. The mean values of elimination half-life, distribution-half, AUC, and volume of distribution were significantly (p<0.01) higher in LEAD-treated group than those in LEAD plus tulsi group (III) The clearance (Cl, mL/kg/h) of SD was slower in LEAD-treated groups than LEAD plus tulsi and control groups The priming dose of SD (mg/kg) in chicks following single i.v. administration is proposed as 68.91 and 122.57 for group I (control), 51.42 and 79.21 for group II (lead) and 61.38 and 106.59 for group III (lead plus tulsi), at 8 h and 12 h interval, respectively. The maintenance doses (Dm, mg/kg) were minimum in group II (39.31 and 57.54) followed by group III (41.03 and 86.25) and control (47.13 and 100.80) at 8 and 12h interval, respectively. It is concluded that feeding of LEAD at 100 ppm dietary level altered the kinetics and dosage regimen of SD which were significantly ameliorated following simultaneous feeding with powdered tulsi (100ppm) in COCKERELS.

Cites

No record.

References

No record.

Cite

APA: Copy

PRAKASH, A., SINGH, P., VARMA, R., CHOUDHARY, G.K., & SAJAN, R.. (2010). PROTECTIVE EFFECT OF OCIMUM SANCTUM ON DISPOSITION KINETICS OF SULPHADIMIDINE IN LEAD-TREATED COCKEREL. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 9(1), 1-5. SID. https://sid.ir/paper/297220/en

Vancouver: Copy

PRAKASH A., SINGH P., VARMA R., CHOUDHARY G.K., SAJAN R.. PROTECTIVE EFFECT OF OCIMUM SANCTUM ON DISPOSITION KINETICS OF SULPHADIMIDINE IN LEAD-TREATED COCKEREL. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2010;9(1):1-5. Available from: https://sid.ir/paper/297220/en

IEEE: Copy

A. PRAKASH, P. SINGH, R. VARMA, G.K. CHOUDHARY, and R. SAJAN, “PROTECTIVE EFFECT OF OCIMUM SANCTUM ON DISPOSITION KINETICS OF SULPHADIMIDINE IN LEAD-TREATED COCKEREL,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 9, no. 1, pp. 1–5, 2010, [Online]. Available: https://sid.ir/paper/297220/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops