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Information Journal Paper

Title

HASHIMOTO ENCEPHALOPATHY: A RARE INTRICATE SYNDROME

Pages

  506-514

Abstract

 Recently, several patients have been reported with various signs of encephalopathy and high thyroid antibody levels together with good responsiveness to glucocorticoid therapy. Despite the various clinical presentations, these cases have been termed “Hashimoto encephalopathy” (HE). Although all of the pathogenic components have not yet been clearly elucidated, it is believed that brain VASCULITIS and autoimmunity directed against common brain-thyroid antigens represent the most likely etiologic pathway. The most common clinical signs include unexplained or epilepsy-like seizures resistant to anticonvulsive treatment, confusion, headaches, hallucinations, stroke-like episodes, coma, impairment of cognitive function, behavioral and mood disturbance, focal neurological deficits, disturbance of consciousness, ataxia, and presenile dementia, together with the presence of high thyroid antibody levels, especially against thyroperoxidase (TPOab). In most cases, the thyroid function is normal or decreased; the thyroid function is rarely increased. The examination of the cerebrospinal fluid, EEG, MRI, SPECT, and neuropsychological examinations are primarily used as diagnostic tools. Most cases showed neural symptoms for months before the acute onset; in some cases, a dramatic acute onset was described. Once the diagnosis is made, corticosteroid treatment usually provides a dramatic recovery. The authors also present a short review of literary cases reported in last decade.

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    APA: Copy

    PAYER, JURAJ, PETROVIC, TOMAS, LISY, LUBOMIR, & LANGER, PAVEL. (2012). HASHIMOTO ENCEPHALOPATHY: A RARE INTRICATE SYNDROME. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 10(2), 506-514. SID. https://sid.ir/paper/297442/en

    Vancouver: Copy

    PAYER JURAJ, PETROVIC TOMAS, LISY LUBOMIR, LANGER PAVEL. HASHIMOTO ENCEPHALOPATHY: A RARE INTRICATE SYNDROME. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2012;10(2):506-514. Available from: https://sid.ir/paper/297442/en

    IEEE: Copy

    JURAJ PAYER, TOMAS PETROVIC, LUBOMIR LISY, and PAVEL LANGER, “HASHIMOTO ENCEPHALOPATHY: A RARE INTRICATE SYNDROME,” INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 10, no. 2, pp. 506–514, 2012, [Online]. Available: https://sid.ir/paper/297442/en

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