140 CASES OF MACROPROLACTINEMIA: SELECTED CLINICAL AND TECHNICAL LABORATORY ASPECTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JESKE WOJCIECH; GLINICKI PIOTR; KAPUSCINSKA RENATA; ZGLICZYNSKI WOJCIECH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Endocrinology and Metabolism Year:2012 | Volume:10 | Issue:1 Page(s): 394-398

Download Full-Text

View:

260

Download:

161

Cites:

Information Journal Paper

Title

140 CASES OF MACROPROLACTINEMIA: SELECTED CLINICAL AND TECHNICAL LABORATORY ASPECTS

Author(s)

JESKE WOJCIECH | GLINICKI PIOTR | KAPUSCINSKA RENATA | ZGLICZYNSKI WOJCIECH | Issue Writer Certificate

Keywords

MACROPROLACTIN

PROLACTIN

Abstract

Background: MACROPROLACTINemia can be an overlooked cause of hyperprolactinemia. To document the presence of MACROPROLACTIN in serum indirectly, an initial precipitation of the complexed PROLACTIN (PRL) using polyethylene glycol (PEG) is followed by measurement of free and total PROLACTIN by immunoassay.Objectives: Adaptation of the PEG method to our PRL immunoassay to detect cases with predominant MACROPROLACTINemia and to study the short- and long-term changes of the relationship between PRL forms.Patients and Methods: One hundred forty hyperprolactinemic patients (aged 17-72 years) in whom MACROPROLACTIN constituted ³ 60% of the total PRL were included in our study.The predominance of MACROPROLACTIN was measured by adapted PEG procedure, followed by immunoradiometric and chemiluminescence methods.Long-term observations with repeated serum PRL measurements were made in 20 cases.For another 20 of 41 patients with indications for metoclopramide (MCP) stimulation test, we analyzed short-term alterations in free and complexed PRL levels.Results: Adjustment of the PEG method by testing samples in dilution minimized the interference of PEG in the immunoassays and let proper detection of predominant MACROPROLACTINemia.During the long-term observations, the ratio of MACROPROLACTIN to total PRL remained relatively constant, independent of changes in total PRL levels. During the MCP test, in the majority of patients with MACROPROLACTINemia (except those with associated PRL-secreting adenoma), an acute rise of PRL level followed by a rise in MACROPROLACTIN resulted in a short-term decrease in MACROPROLACTIN/total PRL ratio.Conclusions: Confirmation of the predominance in serum of MACROPROLACTIN explains the discordance between the raised PRL level and scant of absent symptoms characteristic for hyperprolactinemia. Its proper detection can influence further management.

Cites

No record.

References

No record.

Cite

APA: Copy

JESKE, WOJCIECH, GLINICKI, PIOTR, KAPUSCINSKA, RENATA, & ZGLICZYNSKI, WOJCIECH. (2012). 140 CASES OF MACROPROLACTINEMIA: SELECTED CLINICAL AND TECHNICAL LABORATORY ASPECTS. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 10(1), 394-398. SID. https://sid.ir/paper/297476/en

Vancouver: Copy

JESKE WOJCIECH, GLINICKI PIOTR, KAPUSCINSKA RENATA, ZGLICZYNSKI WOJCIECH. 140 CASES OF MACROPROLACTINEMIA: SELECTED CLINICAL AND TECHNICAL LABORATORY ASPECTS. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2012;10(1):394-398. Available from: https://sid.ir/paper/297476/en

IEEE: Copy

WOJCIECH JESKE, PIOTR GLINICKI, RENATA KAPUSCINSKA, and WOJCIECH ZGLICZYNSKI, “140 CASES OF MACROPROLACTINEMIA: SELECTED CLINICAL AND TECHNICAL LABORATORY ASPECTS,” INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 10, no. 1, pp. 394–398, 2012, [Online]. Available: https://sid.ir/paper/297476/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops