CAN PROCALCITONIN BE AN ACCURATE DIAGNOSTIC MARKER FOR THE CLASSIFICATION OF DIABETIC FOOT ULCERS

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JONAIDI JAFARI NEMATOLLAH; SAFAEE FIROUZABADI MAHDI; IZADI MORTEZA; SAFAEE FIROUZABADI MOHAMMAD SADEGH; SABURI AMIN

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Journal: International Journal of Endocrinology and Metabolism Year:2014 | Volume:12 | Issue:1 Page(s): 0-0

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Title

CAN PROCALCITONIN BE AN ACCURATE DIAGNOSTIC MARKER FOR THE CLASSIFICATION OF DIABETIC FOOT ULCERS

Author(s)

Keywords

INFECTED DIABETIC FOOT ULCER

PROCALCITONIN

INFLAMMATORY MARKER

DIABETIC ARTERIOPATHY

Abstract

Background: The differentiation of INFECTED DIABETIC FOOT ULCERs (IDFU) from non INFECTED DIABETIC FOOT ULCERs (NIDFU) is a challenging issue for clinicians.Objectives: Recently, PROCALCITONIN (PCT) was introduced as a remarkable INFLAMMATORY MARKER. We aimed to evaluate the accuracy of PCT in comparison to other INFLAMMATORY MARKERs for distinguishing IDFU from NIDFU.Materials and Methods: We evaluated PCT serum level as a marker of bacterial infection in patients with diabetic foot ulcers. Sixty patients with diabetic foot ulcers were consecutively enrolled in the study. A total of 30 patients were clinically identified as IDFU by an expert clinician, taking as criteria for purulent discharges or at least two of manifestations of inflammation including warmth, redness, swelling and pain.Results: PROCALCITONIN, white blood cells (WBCs), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP), were found significantly higher in the IDFU group compared to the NIDFU group. The best cut-off value, sensitivity and specificity were 40.5 mm/h, 90% and 94% for ESR, 7.1 mg/dL, 80% and 74% for CRP, 0.21, 70% and 74% for PCT, and 7.7×109/L, 66% and 67% for WBCs, respectively. The area under the receiver operating characteristic curve for ESR was the greatest (0.967; P<0.001), followed by CRP (0.871; P<0.001), PCT (0.729; P<0.001), and finally WBCs (0.721; P=0.001).Conclusions: These results suggest that PCT can be a diagnostic marker in combination with other markers like ESR and CRP to distinguish infected from non-infected foot ulcers, when clinical manifestations are un specific. Additional research is needed before the routine usage of PCT to better define the role of PCT in IDFU.

Cites

Pro-Calcitonin, Erythrocyte Sedimentation Rate and C-reactive Protein in Predicting Diabetic Foot Ulcer Characteristics; a Cross Sectional Study

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APA: Copy

JONAIDI JAFARI, NEMATOLLAH, SAFAEE FIROUZABADI, MAHDI, IZADI, MORTEZA, SAFAEE FIROUZABADI, MOHAMMAD SADEGH, & SABURI, AMIN. (2014). CAN PROCALCITONIN BE AN ACCURATE DIAGNOSTIC MARKER FOR THE CLASSIFICATION OF DIABETIC FOOT ULCERS. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 12(1), 0-0. SID. https://sid.ir/paper/297535/en

Vancouver: Copy

JONAIDI JAFARI NEMATOLLAH, SAFAEE FIROUZABADI MAHDI, IZADI MORTEZA, SAFAEE FIROUZABADI MOHAMMAD SADEGH, SABURI AMIN. CAN PROCALCITONIN BE AN ACCURATE DIAGNOSTIC MARKER FOR THE CLASSIFICATION OF DIABETIC FOOT ULCERS. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2014;12(1):0-0. Available from: https://sid.ir/paper/297535/en

IEEE: Copy

NEMATOLLAH JONAIDI JAFARI, MAHDI SAFAEE FIROUZABADI, MORTEZA IZADI, MOHAMMAD SADEGH SAFAEE FIROUZABADI, and AMIN SABURI, “CAN PROCALCITONIN BE AN ACCURATE DIAGNOSTIC MARKER FOR THE CLASSIFICATION OF DIABETIC FOOT ULCERS,” INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 12, no. 1, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/297535/en

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