Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical Trial

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SOHEILIFAR SARA; BIDGOLI MOHSEN; Hooshyarfard Amir arsalan; Shahbazi Armaghan; VAHDATINIA FARSHID; Khoshkhooie Fahime

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Journal: Frontiers in Dentistry Year:2018 | Volume:15 | Issue:5 Page(s): 309-316

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Title

Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical Trial

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Keywords

Bromelain

Wound Healing

Transplant Donor Site

Operative Surgical Procedure

Abstract

Objectives: Considering the optimal efficacy of Bromelain for pain relief and Wound Healing, this study aimed to assess the effect of Bromelain on Wound Healing, pain, and bleeding at the donor site following free gingival grafting (FGG). Materials and Methods: This randomized, controlled double-blind clinical trial was performed on 26 patients with gingival recession. The patients were randomly divided into two groups of Bromelain and placebo (n=13). Treatment was started on the day of surgery and was continued for 10 days. Pain, bleeding, and epithelialization at the donor site were the variables evaluated in this study using a questionnaire. The level of pain was determined using a visual analog scale (VAS) considering the number of analgesic tablets taken within 7 days postoperatively. Bleeding was determined according to the patient’ s report, and epithelization was assessed by applying 3% hydrogen peroxide (H2O2) to the donor site. The donor site epithelialization was assessed at 7 and 10 days after surgery. Results: Bromelain caused a significant reduction in pain at the donor site (2. 605± 0. 509) compared to the placebo (4. 885± 0. 519; P<0. 05). The number of donor sites with complete epithelialization was higher in the Bromelain group compared to the placebo, but this difference was not statistically significant (P>0. 05). The two groups were the same regarding postoperative bleeding (P>0. 05). Conclusions: The results showed that oral Bromelain (500 mg/day) can be effective in the reduction of pain at the donor site after FGG and may also enhance Wound Healing. Oral Bromelain does not increase the risk of postoperative bleeding.

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APA: Copy

SOHEILIFAR, SARA, BIDGOLI, MOHSEN, Hooshyarfard, Amir arsalan, Shahbazi, Armaghan, VAHDATINIA, FARSHID, & Khoshkhooie, Fahime. (2018). Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical Trial. FRONTIERS IN DENTISTRY (JOURNAL OF DENTISTRY OF TEHRAN UNIVERSITY OF MEDICAL SCIENCES), 15(5), 309-316. SID. https://sid.ir/paper/298115/en

Vancouver: Copy

SOHEILIFAR SARA, BIDGOLI MOHSEN, Hooshyarfard Amir arsalan, Shahbazi Armaghan, VAHDATINIA FARSHID, Khoshkhooie Fahime. Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical Trial. FRONTIERS IN DENTISTRY (JOURNAL OF DENTISTRY OF TEHRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2018;15(5):309-316. Available from: https://sid.ir/paper/298115/en

IEEE: Copy

SARA SOHEILIFAR, MOHSEN BIDGOLI, Amir arsalan Hooshyarfard, Armaghan Shahbazi, FARSHID VAHDATINIA, and Fahime Khoshkhooie, “Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical Trial,” FRONTIERS IN DENTISTRY (JOURNAL OF DENTISTRY OF TEHRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 15, no. 5, pp. 309–316, 2018, [Online]. Available: https://sid.ir/paper/298115/en

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