Efficacy of Octacalcium Phosphate and Octacalcium Phosphate/Gelatin Composite on the Repair of Critical-Sized Calvarial Defects in Rats

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SARGOLZAEI AVAL FEREYDOON; ARAB MOHAMMAD REZA; SARGOLZAEI NARJES; Noushadi Fateme; Eteghadi Abdolsamad; Keykhaei Asadollah; Sargolzaei Aval Foroug; HEDAYATPOUR AZIM

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Journal: Frontiers in Dentistry Year:2018 | Volume:15 | Issue:2 Page(s): 86-96

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Title

Efficacy of Octacalcium Phosphate and Octacalcium Phosphate/Gelatin Composite on the Repair of Critical-Sized Calvarial Defects in Rats

Author(s)

Keywords

Octacalcium Phosphate

Gelatin

Bone Regeneration

Parietal Bone

Rats

Abstract

Objectives: The healing of bone defects in the craniofacial region is an important clinical issue. We aimed to compare the effects of Octacalcium Phosphate (OCP) and the combination of OCP/Gelatin (OCP/Gel) on calvarial Bone Regeneration in Rats. Materials and Methods: In this study, 72 male Sprague Dawley Rats were randomly assigned to the OCP (n=24), OCP/Gel (n=24), and control groups (n=24). Lesions with a diameter of 9 mm were created in the Parietal Bone and were filled with 9-mg OCP and OCP/Gel disks. In the control group, no substance was implanted in the defect. Sampling was performed on days 10, 14, 21, and 28 after the implantation. After tissue processing, 5-μ m sections were prepared and stained by hematoxylin and eosin (H&E) stain. The sections were studied, and the volume fraction of the newly formed bone was assessed by Kruskal-Wallis test at a significance level of 0. 05. Results: In the experimental groups, new bone formation was detected at the margins of the defects 10 days after the implantation. With the progression of the healing process, the newly formed bone covered greater areas of the defects and developed a more mature structure. In the control group, the defects were primarily filled with a dense connective tissue with small islands of new bone. The results of histomorphometric assessments showed that the volume of the newly formed bone in the experimental groups had a significant statistical difference with that in the control group (P<0. 001). Conclusions: The OCP/Gel composite can be useful in the healing process of calvarial bone defects.

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APA: Copy

SARGOLZAEI AVAL, FEREYDOON, ARAB, MOHAMMAD REZA, SARGOLZAEI, NARJES, Noushadi, Fateme, Eteghadi, Abdolsamad, Keykhaei, Asadollah, Sargolzaei Aval, Foroug, & HEDAYATPOUR, AZIM. (2018). Efficacy of Octacalcium Phosphate and Octacalcium Phosphate/Gelatin Composite on the Repair of Critical-Sized Calvarial Defects in Rats. FRONTIERS IN DENTISTRY (JOURNAL OF DENTISTRY OF TEHRAN UNIVERSITY OF MEDICAL SCIENCES), 15(2), 86-96. SID. https://sid.ir/paper/298138/en

Vancouver: Copy

SARGOLZAEI AVAL FEREYDOON, ARAB MOHAMMAD REZA, SARGOLZAEI NARJES, Noushadi Fateme, Eteghadi Abdolsamad, Keykhaei Asadollah, Sargolzaei Aval Foroug, HEDAYATPOUR AZIM. Efficacy of Octacalcium Phosphate and Octacalcium Phosphate/Gelatin Composite on the Repair of Critical-Sized Calvarial Defects in Rats. FRONTIERS IN DENTISTRY (JOURNAL OF DENTISTRY OF TEHRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2018;15(2):86-96. Available from: https://sid.ir/paper/298138/en

IEEE: Copy

FEREYDOON SARGOLZAEI AVAL, MOHAMMAD REZA ARAB, NARJES SARGOLZAEI, Fateme Noushadi, Abdolsamad Eteghadi, Asadollah Keykhaei, Foroug Sargolzaei Aval, and AZIM HEDAYATPOUR, “Efficacy of Octacalcium Phosphate and Octacalcium Phosphate/Gelatin Composite on the Repair of Critical-Sized Calvarial Defects in Rats,” FRONTIERS IN DENTISTRY (JOURNAL OF DENTISTRY OF TEHRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 15, no. 2, pp. 86–96, 2018, [Online]. Available: https://sid.ir/paper/298138/en

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