MUCOADHESIVE AND DRUG RELEASE PROPERTIES OF BENZOCAINE GEL

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JELVEHGARI M.; RASHIDI M.R.; SAMADI H.

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES Year:2006 | Volume:2 | Issue:4 Page(s): 185-194

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Information Journal Paper

Title

MUCOADHESIVE AND DRUG RELEASE PROPERTIES OF BENZOCAINE GEL

Author(s)

JELVEHGARI M. | RASHIDI M.R. | SAMADI H. | Issue Writer Certificate

Keywords

BENZOCAINE

CARBOPOL 934P

DRUG RELEASE RATE

MUCOADHESIVE

Abstract

Gel dosage forms are successfully used as drug delivery systems considering their ability to control drug release and to protect medicaments from a hostile environment. The aim of this work was to investigate the properties of CARBOPOL 934P polymeric system in water-misible co solvents such as glycerin and alcohol. BENZOCAINE is a local anesthetic and the mucosal gel formulation is applied in the treatment of dental pain. Samples were prepared by simply dispersing different amounts of Carbopols (0.5-3%) into the alcoholic solution at the room temperature and were kept at 4,25 and 40 C. All these systems were then characterized for distribution, bioadhesiveness on the mucosa, physical stability and drug release. The silastic membrane was employed. The membrane must not be a barrier for drug transport. Franz diffusion cell used to study in vitro drug release. The increase in carbopol concentration caused increased viscosity and bioadhesiveness. Neutralization of pH in various concentrations of carbopol gels showed resulted in increased viscosity. A relationship between the viscosity and bioadhesive strength was shown in the neutralized carbopol gels. On the other hand, the results indicated that increasing amount of alcohol and glycerin reduced drug release. In contrast, by increasing the amount of water, elasticity and release rate was increased. Vision-gel was used as a reference for comparison with the oromucosal gel formulation. The results showed that diffusion of BENZOCAINE from oromucosal gel and commercial sample followed Higuchi law.

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APA: Copy

JELVEHGARI, M., RASHIDI, M.R., & SAMADI, H.. (2006). MUCOADHESIVE AND DRUG RELEASE PROPERTIES OF BENZOCAINE GEL. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2(4), 185-194. SID. https://sid.ir/paper/300192/en

Vancouver: Copy

JELVEHGARI M., RASHIDI M.R., SAMADI H.. MUCOADHESIVE AND DRUG RELEASE PROPERTIES OF BENZOCAINE GEL. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES[Internet]. 2006;2(4):185-194. Available from: https://sid.ir/paper/300192/en

IEEE: Copy

M. JELVEHGARI, M.R. RASHIDI, and H. SAMADI, “MUCOADHESIVE AND DRUG RELEASE PROPERTIES OF BENZOCAINE GEL,” IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 2, no. 4, pp. 185–194, 2006, [Online]. Available: https://sid.ir/paper/300192/en

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