مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

PROTECTIVE EFFECT OF FOLIC ACID AGAINST APOPTOSIS INDUCED BY ISCHEMIA/REPERFUSION INJURY IN RAT LIVER

Pages

  229-238

Abstract

 The anti-apoptotic gene bcl-2 is located in mitochondria, but it is uncertain whether its expression affects hepatocyte survival in ischemia/reperfusion (I/R) injury. This experiment was designed to evaluate the role of folic acid in expression of bcl- 2 in I/R in rat liver. Eighteen Wister rats were divided into sham-operated control group (C) (n=6), I/R group (n=6), folic acid treated group which received 1 mg/kg/day folic acid by oral route for 7 days before induction of I/R (n=6). Bcl-2 expression was measured by RT-PCR and western blot methods. Folic acid significantly increased Bcl-2 mRNA expression in comparison to the I/R group. Quantification of apoptotic and necrotic hepatocytes, measured by fluorescence microscopy and terminal deoxynucleotidyl transferase (TdT)-mediated dUDPbiotin nick end labeling (TUNEL) method, showed a significant decrease in APOPTOSIS and necrosis of hepatocytes in folic acid-treated group. Histopathological examination of the liver revealed that folic acid protected from severe hepatic degeneration from I/R injury. The biochemical parameters like alanine transaminases and aspartate transaminases were significantly decreased in folic acid-treated group compared to I/R group. In conclusion, folic acid afforded significant protection against I/R injury due to its ability to inhibit I/R-induced APOPTOSIS.

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    Cite

    APA: Copy

    CHATTOPADHYAY, P., SHARMA, A., CHAUDHURI, P., & WAHI, A.K.. (2007). PROTECTIVE EFFECT OF FOLIC ACID AGAINST APOPTOSIS INDUCED BY ISCHEMIA/REPERFUSION INJURY IN RAT LIVER. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 3(4), 229-238. SID. https://sid.ir/paper/300228/en

    Vancouver: Copy

    CHATTOPADHYAY P., SHARMA A., CHAUDHURI P., WAHI A.K.. PROTECTIVE EFFECT OF FOLIC ACID AGAINST APOPTOSIS INDUCED BY ISCHEMIA/REPERFUSION INJURY IN RAT LIVER. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES[Internet]. 2007;3(4):229-238. Available from: https://sid.ir/paper/300228/en

    IEEE: Copy

    P. CHATTOPADHYAY, A. SHARMA, P. CHAUDHURI, and A.K. WAHI, “PROTECTIVE EFFECT OF FOLIC ACID AGAINST APOPTOSIS INDUCED BY ISCHEMIA/REPERFUSION INJURY IN RAT LIVER,” IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 3, no. 4, pp. 229–238, 2007, [Online]. Available: https://sid.ir/paper/300228/en

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