مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

699
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

467
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

HYPOGLYCEMIC ACTIVITY OF RUELLIA TUBEROSA LINN (ACANTHACEAE) IN NORMAL AND ALLOXAN-INDUCED DIABETIC RABBITS

Pages

  107-115

Abstract

 The present study was carried out to determine the HYPOGLYCEMIC ACTIVITY of the methanolic extract and solvent fractions (n-hexane and ethyl acetate) of Ruellia tuberosain normal and alloxan-induced diabetic rabbits. OPTIMUM DOSE of R.tuberosafor HYPOGLYCEMIC ACTIVITY was determined by oral administration of the methanolic extract (ME) to normal and diabetic rabbits. Diabetes was induced by intra-peritoneal injection of alloxan monohydrate (150 mg/kg). Hypoglycemic effect of n-hexane (HF) and ethyl acetate (EF) fractions was evaluated at a dose of 150 and 100 mg/kg b.w., respectively, in normal and diabetic rabbits. Administration of the OPTIMUM DOSE (500 mg/kg b.w.) ofR. tuberosa to normal and diabetic rabbits showed significant blood glucose lowering effect. EaF (100 mg/kg) showed the highest anti-diabetic activity with 28.64±0.28% decrease in blood glucose, while HF (150 mg/kg) showed moderate anti-diabetic activity and lowered the blood glucose level around 15.17±0.58%. The results were compared with the standard drug tolbutamide (100 mg/kg). Phytochemical investigation of EF and HF indicated flavonoids and triterpenoids in the extracts, respectively. Antioxidant activity was evaluated by DPPH method and the amount of total phenols was determined by Folin-Ciocalteu method. ME extract and its fractions showed the antioxidant activity in the order of EF>ME>WF>HF. The results were in agreement with the folkloric use ofR. tuberosa in the treatment of diabetes and related complications.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    SHAHWAR, DURRE, ULLAH, SAIF, AHMAD, MOBASHER, ULLAH, SAMI, AHMAD, NAEEM, & AKMAL KHAN, MUHAMMAD. (2011). HYPOGLYCEMIC ACTIVITY OF RUELLIA TUBEROSA LINN (ACANTHACEAE) IN NORMAL AND ALLOXAN-INDUCED DIABETIC RABBITS. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 7(2), 107-115. SID. https://sid.ir/paper/300316/en

    Vancouver: Copy

    SHAHWAR DURRE, ULLAH SAIF, AHMAD MOBASHER, ULLAH SAMI, AHMAD NAEEM, AKMAL KHAN MUHAMMAD. HYPOGLYCEMIC ACTIVITY OF RUELLIA TUBEROSA LINN (ACANTHACEAE) IN NORMAL AND ALLOXAN-INDUCED DIABETIC RABBITS. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES[Internet]. 2011;7(2):107-115. Available from: https://sid.ir/paper/300316/en

    IEEE: Copy

    DURRE SHAHWAR, SAIF ULLAH, MOBASHER AHMAD, SAMI ULLAH, NAEEM AHMAD, and MUHAMMAD AKMAL KHAN, “HYPOGLYCEMIC ACTIVITY OF RUELLIA TUBEROSA LINN (ACANTHACEAE) IN NORMAL AND ALLOXAN-INDUCED DIABETIC RABBITS,” IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 7, no. 2, pp. 107–115, 2011, [Online]. Available: https://sid.ir/paper/300316/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button