HEPATOPROTECTIVE ACTIVITY OF MOMORDICA DIOCIA ROXB FRUITS IN CCL4-INDUCED HEPATOTOXICITY IN RATS

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SHANKAR P.; PRASANNA KUMAR B.R.; KHALLEL MOHAMMED

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES Year:2011 | Volume:7 | Issue:4 Page(s): 279-282

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Title

HEPATOPROTECTIVE ACTIVITY OF MOMORDICA DIOCIA ROXB FRUITS IN CCL4-INDUCED HEPATOTOXICITY IN RATS

Author(s)

SHANKAR P. | PRASANNA KUMAR B.R. | KHALLEL MOHAMMED | Issue Writer Certificate

Keywords

HEPATPROTECTIVE ACTIVITY

MOMORDICIA DIOCIA FRUITS

Abstract

Fruits, leaves and tuberous roots of Momordicia diocia are used in India as a folk remedy for treatment of a wide range of disorders. The objective of this study was to evaluate the HEPATPROTECTIVE ACTIVITY of the fruits of Momordicia diocia by preparing different extracts and the resultant extract were screened for the HEPATPROTECTIVE ACTIVITY. The ethyl acetate and ethanolic extracts of MOMORDICIA DIOCIA FRUITS were prepared and subjected for phytochemical screening and tested for their HEPATPROTECTIVE ACTIVITY in CCl4-induced hepatotoxicity in rats. Phytochemical screening showed positive test for steroids, triterpenoids and glycosides (Etoh extract). The ethyl acetate and ethanolic extracts showed a significant HEPATPROTECTIVE ACTIVITY at a dose of 200 mg/kg (p.o.). The results suggested that Momordica diociafruits possess potential HEPATPROTECTIVE ACTIVITY against CCl4 hepatotoxicity possibly by antioxidant activity.

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APA: Copy

SHANKAR, P., PRASANNA KUMAR, B.R., & KHALLEL, MOHAMMED. (2011). HEPATOPROTECTIVE ACTIVITY OF MOMORDICA DIOCIA ROXB FRUITS IN CCL₄-INDUCED HEPATOTOXICITY IN RATS. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 7(4), 279-282. SID. https://sid.ir/paper/300334/en

Vancouver: Copy

SHANKAR P., PRASANNA KUMAR B.R., KHALLEL MOHAMMED. HEPATOPROTECTIVE ACTIVITY OF MOMORDICA DIOCIA ROXB FRUITS IN CCL₄-INDUCED HEPATOTOXICITY IN RATS. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES[Internet]. 2011;7(4):279-282. Available from: https://sid.ir/paper/300334/en

IEEE: Copy

P. SHANKAR, B.R. PRASANNA KUMAR, and MOHAMMED KHALLEL, “HEPATOPROTECTIVE ACTIVITY OF MOMORDICA DIOCIA ROXB FRUITS IN CCL₄-INDUCED HEPATOTOXICITY IN RATS,” IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 7, no. 4, pp. 279–282, 2011, [Online]. Available: https://sid.ir/paper/300334/en

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