مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

The Effect of Some Herbal Extracts on Nitric Oxide Production in Endothelial Cells 3T3 Cell Line

Pages

  1-10

Abstract

 Some studies have demonstrated the potential of herbal drugs for the treatment of various diseases associated with impaired vascular Nitric oxide (NO). For diagnosis of the mechanism of these herbal plants, it seems necessary to evaluate the herbal extracts on the Endothelium cell. The aim of the study was to investigate the effect of extract of Trigonella foenum-graecum (T. foenum), Nigella sativa (NS), Allium sativum, and Cannabis sativa on Nitric oxide (NO) production by the Endothelial cells 3T3 cell line. Ground herbs suspended in water and methanol, were filtered and concentrated under pressure. Remaining contents were dried and obtained powder dissolved in water. The cell line was treated with plant extracts. The clarified supernatant of the culture was used for evaluation of quantitative changes in NO production using Griess test. Among the four extracts, only the group treated with T. foenum extract, significantly increased NO production compared to the control group. Also, NO concentration in other extract group was lower than T. foenum group. This study suggested that the T. foenum extract can significantly increase NO concentration in cell culture and the increase in Nitric oxide production is because of the presence of diosgenin T. foenum extracted.

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    APA: Copy

    MOHEBBATI, REZA, Iranmanesh, Mozhdeh, BEHESHTI, FARIMAH, MOUSAVI, MOJTABA, Rohani, Mina, MOGHARRABI, MARZIEH, & SOUKHTANLOO, MOHAMMAD. (2016). The Effect of Some Herbal Extracts on Nitric Oxide Production in Endothelial Cells 3T3 Cell Line. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 12(3), 1-10. SID. https://sid.ir/paper/300421/en

    Vancouver: Copy

    MOHEBBATI REZA, Iranmanesh Mozhdeh, BEHESHTI FARIMAH, MOUSAVI MOJTABA, Rohani Mina, MOGHARRABI MARZIEH, SOUKHTANLOO MOHAMMAD. The Effect of Some Herbal Extracts on Nitric Oxide Production in Endothelial Cells 3T3 Cell Line. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES[Internet]. 2016;12(3):1-10. Available from: https://sid.ir/paper/300421/en

    IEEE: Copy

    REZA MOHEBBATI, Mozhdeh Iranmanesh, FARIMAH BEHESHTI, MOJTABA MOUSAVI, Mina Rohani, MARZIEH MOGHARRABI, and MOHAMMAD SOUKHTANLOO, “The Effect of Some Herbal Extracts on Nitric Oxide Production in Endothelial Cells 3T3 Cell Line,” IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 12, no. 3, pp. 1–10, 2016, [Online]. Available: https://sid.ir/paper/300421/en

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