ASSOCIATION BETWEEN ANDROGENIC HORMONE LEVELS AND LEFT VENTRICULAR EJECTION FRACTION

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DAVOUDI GH.R.; AMIRZADEGAN A.R.; BOROUMAND M.A.; RAEISI DEHKORDI MARIA; KAZEMI SAEID A.; YAMINI SHARIF A.; REZVANFARD MEHRNAZ; SOTOUDEH ANVARI M.

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Journal: THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER Year:2010 | Volume:5 | Issue:3 Page(s): 141-145

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Title

ASSOCIATION BETWEEN ANDROGENIC HORMONE LEVELS AND LEFT VENTRICULAR EJECTION FRACTION

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Keywords

TESTOSTERONE

ANDROGENS

HEART FAILURE

VENTRICULAR FUNCTION

LEFT

Abstract

Background: ANDROGENS have been shown to have diverse effects on the cardiovascular system. The aim of this study was to compare androgenic hormone levels in patients with different LEFT ventricular ejection fractions (EF).Methods: The study population consisted of 515 consecutive men who were referred for angiographic studies and whose results of echocardiography and coronary angiography were available. The patients were classified into four groups: EF<35%, EF=35-45%, EF=45-54%, and EF³55% to evaluate the trends of baseline characteristics and serum ANDROGENS, including free TESTOSTERONE (fT), total TESTOSTERONE (tT), and dehydroepiandrosterone sulfate (DHEAS). To better elucidate the difference in the patients with severe HEART FAILURE, the patients were divided into two groups according to their EF level, and comparisons were repeated between those with EF<35% and the ones with EF ≥ 35%.Results: There were statistically significant trends in some characteristics in the patients with different levels of EF. The subjects with higher EF levels were less likely to have diabetes (p value<0.001), coronary artery lesion (p value<0.001), or high levels of C-reactive protein (CRP) (p value<0.001). As regards the patients with severe HEART FAILURE, our regression analysis revealed that the fT level was significantly lower in those with EF<35% than in the ones with EF³35% (5.82±2.73 pg/mL vs. 6.88 ± 3.34 pg/mL, p value<0.05).Conclusion: A significant association was found between the level of fT and EF<35%. There is a need for further controlled prospective studies to delineate any possible causal relationship accurately.

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APA: Copy

DAVOUDI, GH.R., AMIRZADEGAN, A.R., BOROUMAND, M.A., RAEISI DEHKORDI, MARIA, KAZEMI SAEID, A., YAMINI SHARIF, A., REZVANFARD, MEHRNAZ, & SOTOUDEH ANVARI, M.. (2010). ASSOCIATION BETWEEN ANDROGENIC HORMONE LEVELS AND LEFT VENTRICULAR EJECTION FRACTION. THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER, 5(3), 141-145. SID. https://sid.ir/paper/301956/en

Vancouver: Copy

DAVOUDI GH.R., AMIRZADEGAN A.R., BOROUMAND M.A., RAEISI DEHKORDI MARIA, KAZEMI SAEID A., YAMINI SHARIF A., REZVANFARD MEHRNAZ, SOTOUDEH ANVARI M.. ASSOCIATION BETWEEN ANDROGENIC HORMONE LEVELS AND LEFT VENTRICULAR EJECTION FRACTION. THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER[Internet]. 2010;5(3):141-145. Available from: https://sid.ir/paper/301956/en

IEEE: Copy

GH.R. DAVOUDI, A.R. AMIRZADEGAN, M.A. BOROUMAND, MARIA RAEISI DEHKORDI, A. KAZEMI SAEID, A. YAMINI SHARIF, MEHRNAZ REZVANFARD, and M. SOTOUDEH ANVARI, “ASSOCIATION BETWEEN ANDROGENIC HORMONE LEVELS AND LEFT VENTRICULAR EJECTION FRACTION,” THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER, vol. 5, no. 3, pp. 141–145, 2010, [Online]. Available: https://sid.ir/paper/301956/en

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