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Information Journal Paper

Title

RELATIONSHIP BETWEEN CALCIUM-PHOSPHORUS PRODUCT AND SEVERITY OF VALVULAR HEART INSUFFICIENCY IN PATIENTS UNDERGOING CHRONIC HEMODIALYSIS

Pages

  78-82

Abstract

 Background: Recent interests have mainly focused on the roles of serum CALCIUM and PHOSPHORUS and their product (Ca-P product) in the development of valvular heart disease. The present study assessed the relationship between the Ca-P product and the severity of valvular heart disease in end-stage renal disease (ESRD) patients undergoing chronic hemodialysis.Methods: This cross-sectional study reviewed the clinical course of 72 consecutive patients with the final diagnosis of ESRD candidated for chronic hemodialysis. The severity of valvular heart disease was determined using M-mode two-dimensional echocardiography. The serum CALCIUM and phosphate values adopted were those values measured on the day between the two consecutive dialyses, and the Ca-P product was calculated.Results: The most common causes of ESRD were diabetic nephropathy, malignant hypertension, and chronic glomerulonephritis. The mean Ca-P product level in the dialysis patients was 50.4±17.78 mg2/dL2. The receiver-operator characteristic (ROC) curve illustrated that a Ca-P product level > 42 mg2/dL2 was the optimal value in terms of sensitivity and specificity for predicting the presence of valvular insufficiency. Aortic insufficiency was directly associated with a high Ca-P product value after adjustment for age, gender, serum albumin, diabetes, hypertension, hyperlipidemia, coronary artery disease, and serum creatinine (b=0.412, SE=158, p value=0.011).Conclusion: A positive relationship between the Ca-P product value and the severity of aortic insufficiency is expected. Achieving an appropriate control of the Ca-P product level may decrease aortic valve calcification and improve the survival of patients on chronic hemodialysis.

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    Cite

    APA: Copy

    KAHNOUJ, M., MASOUMI, MOHAMMAD, NADERINASAB, A., ZAEIM, A., & SHEYKH VATAN, M.. (2010). RELATIONSHIP BETWEEN CALCIUM-PHOSPHORUS PRODUCT AND SEVERITY OF VALVULAR HEART INSUFFICIENCY IN PATIENTS UNDERGOING CHRONIC HEMODIALYSIS. THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER, 5(2), 78-82. SID. https://sid.ir/paper/301964/en

    Vancouver: Copy

    KAHNOUJ M., MASOUMI MOHAMMAD, NADERINASAB A., ZAEIM A., SHEYKH VATAN M.. RELATIONSHIP BETWEEN CALCIUM-PHOSPHORUS PRODUCT AND SEVERITY OF VALVULAR HEART INSUFFICIENCY IN PATIENTS UNDERGOING CHRONIC HEMODIALYSIS. THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER[Internet]. 2010;5(2):78-82. Available from: https://sid.ir/paper/301964/en

    IEEE: Copy

    M. KAHNOUJ, MOHAMMAD MASOUMI, A. NADERINASAB, A. ZAEIM, and M. SHEYKH VATAN, “RELATIONSHIP BETWEEN CALCIUM-PHOSPHORUS PRODUCT AND SEVERITY OF VALVULAR HEART INSUFFICIENCY IN PATIENTS UNDERGOING CHRONIC HEMODIALYSIS,” THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER, vol. 5, no. 2, pp. 78–82, 2010, [Online]. Available: https://sid.ir/paper/301964/en

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