ANALYZING GENSINI SCORE AS A SEMI-CONTINUOUS OUTCOME

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KASHANI HOMA; ZERAATI HOJJAT; MOHAMMAD KAZEM; GOODARZYNEJAD HAMIDREZA; MAHMOUDI MAHMOOD; SADEGHIAN SAEED; BOROUMAND MOHAMMADALI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER Year:2016 | Volume:11 | Issue:2 Page(s): 55-61

Download Full-Text

View:

239

Download:

Cites:

Information Journal Paper

Title

ANALYZING GENSINI SCORE AS A SEMI-CONTINUOUS OUTCOME

Author(s)

Keywords

CORONARY ARTERY DISEASE

CORONARY ANGIOGRAPHY

DATA INTERPRETATION

STATISTICAL

Abstract

Background: Investigators frequently encounter continuous outcomes with plenty of values clumped at zero called semicontinuous outcomes. The Gensini score, one of the most widely used scoring systems for expressing coronary angiographic results, is of this type. The aim of this study was to apply two STATISTICAL approaches based on the categorization and original scale of the Gensini score to simultaneously assess the association between covariates and the presence and severity of CORONARY ARTERY DISEASE (CAD).Methods: We considered the data on 1594 individuals admitted to Tehran Heart Center with CAD symptoms from July 2004 to February 2008. The participants’ baseline demographic and clinical characteristics were collected, and their coronary angiographic results were expressed through the Gensini score. The generalized ordinal threshold and two-part models were applied for the STATISTICAL analyses.Results: Totally, 320 (20.1%) individuals had a Gensini score of zero. The results of neither the two-part model nor the generalized ordinal threshold model showed a significant association between Factor V Leiden and the occurrence of CAD.However, based on the two-part model, Factor V Leiden was associated with the severity of CAD, such that the Gensini score increased by moving from a wild genotype to a heterozygote (b=0.44; 95% CI: 0.20-0.69 in logarithm scale) or a homozygote mutant (b=0.70; 95% CI: 0.28- 1.12 in logarithm scale). The proportional odds assumption was not met in our data (χ2= 54.26; p value<0.001); however, a trend toward severe CAD was also observed at each category of the Gensini score using the generalized ordinal threshold model.Conclusion: We conclude that besides loss of information by sorting a semi-continuous outcome, violation from the proportional odds assumption complicates the final decision, especially for clinicians. Therefore, more straightforward models such as the two-part model should receive more attention while analyzing such outcomes.

Cites

No record.

References

No record.

Cite

APA: Copy

KASHANI, HOMA, ZERAATI, HOJJAT, MOHAMMAD, KAZEM, GOODARZYNEJAD, HAMIDREZA, MAHMOUDI, MAHMOOD, SADEGHIAN, SAEED, & BOROUMAND, MOHAMMADALI. (2016). ANALYZING GENSINI SCORE AS A SEMI-CONTINUOUS OUTCOME. THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER, 11(2), 55-61. SID. https://sid.ir/paper/302046/en

Vancouver: Copy

KASHANI HOMA, ZERAATI HOJJAT, MOHAMMAD KAZEM, GOODARZYNEJAD HAMIDREZA, MAHMOUDI MAHMOOD, SADEGHIAN SAEED, BOROUMAND MOHAMMADALI. ANALYZING GENSINI SCORE AS A SEMI-CONTINUOUS OUTCOME. THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER[Internet]. 2016;11(2):55-61. Available from: https://sid.ir/paper/302046/en

IEEE: Copy

HOMA KASHANI, HOJJAT ZERAATI, KAZEM MOHAMMAD, HAMIDREZA GOODARZYNEJAD, MAHMOOD MAHMOUDI, SAEED SADEGHIAN, and MOHAMMADALI BOROUMAND, “ANALYZING GENSINI SCORE AS A SEMI-CONTINUOUS OUTCOME,” THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER, vol. 11, no. 2, pp. 55–61, 2016, [Online]. Available: https://sid.ir/paper/302046/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops