Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease

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Noori Noor Mohammand; SHAHRAMIAN IRAJ; TEIMOURI ALIREZA; Keyvani Behrooz; MAHJOUBIFARD MAZIAR

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Journal: THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER Year:2017 | Volume:12 | Issue:1 Page(s): 15-22

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Title

Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease

Author(s)

Keywords

Tumor necrosis factor-alpha

Interleukins

Child

Heart defects

congenital

Abstract

Background: Levels of anti-inflammatory cytokines in blood have a positive relationship with congenital heart disease (CHD). We sought to assess the difference in serum cytokines levels between Children with and without CHD. Methods: We recruited 60 patients with CHD and 30 healthy Children, from 2013 to 2014. Patients with primary pulmonary hypertension; metabolic diseases; renal, endocrine, and chronic inflammatory diseases; fever; infection in the preceding 3 weeks; and malnutrition were excluded. Participants’ demographic data were measured, and their cardiac diseases were diagnosed via echocardiography. Serum levels of tumor necrosis factor (TNF)-α , interleukin (IL)-6, and IL-18 were measured via ELISA. Results: Mean age of the participants was 4. 28 ± 3. 44, 3. 12 ± 3. 87, and 3. 30 ± 3. 61 years in the cyanotic, acyanotic, and control groups, respectively (p value = 0. 414). Mean values of TNF-α (p value < 0. 001), IL-6 (p value < 0. 001), IL-18 (p value = 0. 030), right ventricular pressure (p value < 0. 001), and pulmonary pressure (p value = 0. 015) were higher in the case group, while the BMI was higher in the controls (p value < 0. 001). Mean values of TNF-α (p value < 0. 001), IL-6 (p value < 0. 001), and right ventricular pressure (p value < 0. 001) were significantly higher in the cyanotic Children, whereas the BMI was higher in the controls (p value < 0. 001). Levels of TNF-α and IL-6 had significant correlations with right ventricular pressure. Conclusion: The present study showed a differed serum cytokines levels between Children with and without CHD.

Cites

Tumor Necrosis Factor alpha, N-terminal Pro Brain Natriuretic Peptide and Interleukin-6 Correlations with Doppler Tissue Imaging findings in Major Thalassemia Patients

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APA: Copy

Noori, Noor Mohammand, SHAHRAMIAN, IRAJ, TEIMOURI, ALIREZA, Keyvani, Behrooz, & MAHJOUBIFARD, MAZIAR. (2017). Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease. THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER, 12(1), 15-22. SID. https://sid.ir/paper/302134/en

Vancouver: Copy

Noori Noor Mohammand, SHAHRAMIAN IRAJ, TEIMOURI ALIREZA, Keyvani Behrooz, MAHJOUBIFARD MAZIAR. Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease. THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER[Internet]. 2017;12(1):15-22. Available from: https://sid.ir/paper/302134/en

IEEE: Copy

Noor Mohammand Noori, IRAJ SHAHRAMIAN, ALIREZA TEIMOURI, Behrooz Keyvani, and MAZIAR MAHJOUBIFARD, “Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease,” THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER, vol. 12, no. 1, pp. 15–22, 2017, [Online]. Available: https://sid.ir/paper/302134/en

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