Nephroprotective Effects of L-Carnitine against Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Open-Labeled Clinical Trial

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MOHAMMADI MOHAMMAD; HAJHOSSEIN TALASAZ AZITA; ALIDOOSTI MOHAMMAD; POURHOSSEINI HAMIDREZA; GHOLAMI KHEIROLLAH; JALALI ARASH; Aryannejad Hamid

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Journal: THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER Year:2017 | Volume:12 | Issue:2 Page(s): 57-64

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Title

Nephroprotective Effects of L-Carnitine against Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Open-Labeled Clinical Trial

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Keywords

Coronary artery disease

Angioplasty

Contrast medium

Acute kidney injury

Kidney diseases

Abstract

Background: L-carnitine may prevent the incidence of AKI by its antioxidant effects and improving circulation in ischemic conditions. The goal of this trial was to evaluate the impact of L-carnitine on contrast-induced nephropathy in patients undergoing elective PCI. Methods: Totally, the patients were randomly allocated to 2 groups. The treatment group received 1 g of L-carnitine orally 3 times a day, 24 hours before the procedure (3 g before PCI) and 2 g after PCI, whereas the control group did not receive L-carnitine. In both groups, the plasma level of neutrophil gelatinase-associated lipocalin (NGAL) was measured at baseline and 12 hours after PCI. Results: Our study was conducted on 202 patients (including 91 vs. 111 patients in the treatment and the control group; 31 (34. 1%) vs 33 (29. 7%) female in carnitine and control group; and ages include 62. 0 ± 9. 0 vs 57. 0 ± 11. 2 years). The median plasma levels of NGAL were not different between the carnitine and control groups at baseline (57 [IQR: 22 – 255] vs. 54 [IQR: 29 – 324]; p value = 0. 155) and 12 hours after PCI (71 [IQR: 52 – 129] vs. 70 [IQR: 46 – 153]; p value = 0. 925), but the changes in the plasma NGAL from baseline to 12 hours after PCI were different between the 2 groups (5 [IQR:-147 – 30] vs. 17 [IQR:-21 – 41]; p value = 0. 010). Conclusion: Our results showed that oral L-carnitine was able to prevent an increase in NGAL following Contrast medium administration in patients undergoing PCI. More studies should be performed to fully elucidate the nephroprotective effects of L-carnitine.

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APA: Copy

MOHAMMADI, MOHAMMAD, HAJHOSSEIN TALASAZ, AZITA, ALIDOOSTI, MOHAMMAD, POURHOSSEINI, HAMIDREZA, GHOLAMI, KHEIROLLAH, JALALI, ARASH, & Aryannejad, Hamid. (2017). Nephroprotective Effects of L-Carnitine against Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Open-Labeled Clinical Trial. THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER, 12(2), 57-64. SID. https://sid.ir/paper/302148/en

Vancouver: Copy

MOHAMMADI MOHAMMAD, HAJHOSSEIN TALASAZ AZITA, ALIDOOSTI MOHAMMAD, POURHOSSEINI HAMIDREZA, GHOLAMI KHEIROLLAH, JALALI ARASH, Aryannejad Hamid. Nephroprotective Effects of L-Carnitine against Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Open-Labeled Clinical Trial. THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER[Internet]. 2017;12(2):57-64. Available from: https://sid.ir/paper/302148/en

IEEE: Copy

MOHAMMAD MOHAMMADI, AZITA HAJHOSSEIN TALASAZ, MOHAMMAD ALIDOOSTI, HAMIDREZA POURHOSSEINI, KHEIROLLAH GHOLAMI, ARASH JALALI, and Hamid Aryannejad, “Nephroprotective Effects of L-Carnitine against Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Open-Labeled Clinical Trial,” THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER, vol. 12, no. 2, pp. 57–64, 2017, [Online]. Available: https://sid.ir/paper/302148/en

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