مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

Effects of Endothelial and Mesenchymal Stem Cells on Improving Myocardial Function in a Sheep Animal Model

Pages

  65-71

Abstract

 Background: Myocardial infarction is the main cause of death worldwide. Angiogenesis, a promising new therapy for the treatment of diffuse coronary artery disease, shows a poor response to conventional revascularization techniques. This study focused on improving myocardial function using Endothelial cells (ECs) and mesenchymal stem cells (MSCs) in a Sheep animal model. Methods: Acute Myocardial infarction was induced in 18 Sheep (12 treated cases and 6 controls). Autologous MSCs and ECs were injected in the infarcted area and the border zone. Two months after transplantation, echocardiography, electron microscopy, and immunohistochemistry were performed. Results: Echocardiography in both MSC and EC groups revealed a significant improvement in the ejection fraction compared with the control group (p value < 0. 05). Vascular density, estimated by antibodies against the von Willebrand factor and smooth muscle actin, increased in both study groups. The pattern of vascularity in the MSC and EC groups was diffused. The electron microscopic evaluation of the infracted areas revealed cardiomyocytes in variable stages of development in the border zone in both EC and MSC groups. Conclusion: Both ECs and MSCs were able to promote angiogenesis and improve cardiac function. Presumably, MSCs differentiate into ECs and cause angiogenesis as it occurs for ECs.

Cites

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    • Cite

    APA: Copy

    RABBANI, SHAHRAM, SOLEIMANI, MASOUD, SAHEBJAM, MOHAMMAD, IMANI, MOHAMMAD, Nassiri, Seyed Mahdi, ATASHI, AMIR, DALIRI JOUPARI, MORTEZA, GHIASEDDIN, ALI, LATIFPOUR, MOSTAFA, & AHMADI TAFTI, SEYED HOSSEIN. (2017). Effects of Endothelial and Mesenchymal Stem Cells on Improving Myocardial Function in a Sheep Animal Model. THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER, 12(2), 65-71. SID. https://sid.ir/paper/302150/en

    Vancouver: Copy

    RABBANI SHAHRAM, SOLEIMANI MASOUD, SAHEBJAM MOHAMMAD, IMANI MOHAMMAD, Nassiri Seyed Mahdi, ATASHI AMIR, DALIRI JOUPARI MORTEZA, GHIASEDDIN ALI, LATIFPOUR MOSTAFA, AHMADI TAFTI SEYED HOSSEIN. Effects of Endothelial and Mesenchymal Stem Cells on Improving Myocardial Function in a Sheep Animal Model. THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER[Internet]. 2017;12(2):65-71. Available from: https://sid.ir/paper/302150/en

    IEEE: Copy

    SHAHRAM RABBANI, MASOUD SOLEIMANI, MOHAMMAD SAHEBJAM, MOHAMMAD IMANI, Seyed Mahdi Nassiri, AMIR ATASHI, MORTEZA DALIRI JOUPARI, ALI GHIASEDDIN, MOSTAFA LATIFPOUR, and SEYED HOSSEIN AHMADI TAFTI, “Effects of Endothelial and Mesenchymal Stem Cells on Improving Myocardial Function in a Sheep Animal Model,” THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER, vol. 12, no. 2, pp. 65–71, 2017, [Online]. Available: https://sid.ir/paper/302150/en

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