THE EFFECTS OF EIGHT-WEEK TREATMENT WITH HIGH DOSE VITAMIN E ON SERUM CHOLESTEROL AND TRIGLYCERIDE LEVEL OF PATIENTS WITH SCHIZOPHRENIA ON OLANZAPINE: A PLACEBO CONTROLLED STUDY

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JAZAYERI MARYAM; BAROYANT SALMASI F.; GHAELI P.; HASHEMIAN FARSHAD; ZAHIR ALDIN A.R.; AKHOUNDZADEH SH.; RAEISI FIROUZEH; GOLCHIN K.; AFGHAH S.; BAJOGHLI H.

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Journal: Iranian Journal of Psychiatry Year:2008 | Volume:3 | Issue:1 Page(s): 43-45

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Title

THE EFFECTS OF EIGHT-WEEK TREATMENT WITH HIGH DOSE VITAMIN E ON SERUM CHOLESTEROL AND TRIGLYCERIDE LEVEL OF PATIENTS WITH SCHIZOPHRENIA ON OLANZAPINE: A PLACEBO CONTROLLED STUDY

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Keywords

CHOLESTEROL

OLANZAPINE

SCHIZOPHRENIA

TRIGLYCERIDE

VITAMIN E

Abstract

Objective: To study the effects of a high dose alpha-tocopherol on serum total CHOLESTEROL (TC), TRIGLYCERIDE (TG), and the high density lipoprotein (HDL) levels of patients with SCHIZOPHRENIA receiving OLANZAPINE.Method: Thirty six adults diagnosed with SCHIZOPHRENIA based on DSM-IV who were taking OLANZAPINE for a minimum of thirty days entered this eight-week, double blind, and placebo-controlled study. Patients were randomized to receive alpha-tocopherol 400IU or placebo capsules twice a day for 2 weeks, then three times a day for 6 more weeks. Fasting total CHOLESTEROL (TC), TRIGLYCERIDE (TG), and HDL levels were measured at the baseline and weeks 4 and 8.Results: TC, TG and HDL levels did not change significantly during this study. There were no significant differences in TC, TG and HDL levels between the two groups at the baseline and weeks 4 and 8.Conclusion: High-dose vitamin may not improve TRIGLYCERIDE and CHOLESTEROL levels in patients who are already on OLANZAPINE. Further studies with greater number of patients and for a longer duration are needed.

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APA: Copy

JAZAYERI, MARYAM, BAROYANT SALMASI, F., GHAELI, P., HASHEMIAN, FARSHAD, ZAHIR ALDIN, A.R., AKHOUNDZADEH, SH., RAEISI, FIROUZEH, GOLCHIN, K., AFGHAH, S., & BAJOGHLI, H.. (2008). THE EFFECTS OF EIGHT-WEEK TREATMENT WITH HIGH DOSE VITAMIN E ON SERUM CHOLESTEROL AND TRIGLYCERIDE LEVEL OF PATIENTS WITH SCHIZOPHRENIA ON OLANZAPINE: A PLACEBO CONTROLLED STUDY. IRANIAN JOURNAL OF PSYCHIATRY, 3(1), 43-45. SID. https://sid.ir/paper/302259/en

Vancouver: Copy

JAZAYERI MARYAM, BAROYANT SALMASI F., GHAELI P., HASHEMIAN FARSHAD, ZAHIR ALDIN A.R., AKHOUNDZADEH SH., RAEISI FIROUZEH, GOLCHIN K., AFGHAH S., BAJOGHLI H.. THE EFFECTS OF EIGHT-WEEK TREATMENT WITH HIGH DOSE VITAMIN E ON SERUM CHOLESTEROL AND TRIGLYCERIDE LEVEL OF PATIENTS WITH SCHIZOPHRENIA ON OLANZAPINE: A PLACEBO CONTROLLED STUDY. IRANIAN JOURNAL OF PSYCHIATRY[Internet]. 2008;3(1):43-45. Available from: https://sid.ir/paper/302259/en

IEEE: Copy

MARYAM JAZAYERI, F. BAROYANT SALMASI, P. GHAELI, FARSHAD HASHEMIAN, A.R. ZAHIR ALDIN, SH. AKHOUNDZADEH, FIROUZEH RAEISI, K. GOLCHIN, S. AFGHAH, and H. BAJOGHLI, “THE EFFECTS OF EIGHT-WEEK TREATMENT WITH HIGH DOSE VITAMIN E ON SERUM CHOLESTEROL AND TRIGLYCERIDE LEVEL OF PATIENTS WITH SCHIZOPHRENIA ON OLANZAPINE: A PLACEBO CONTROLLED STUDY,” IRANIAN JOURNAL OF PSYCHIATRY, vol. 3, no. 1, pp. 43–45, 2008, [Online]. Available: https://sid.ir/paper/302259/en

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