Environmental Enrichment Prevents Methamphetamine-Induced Spatial Memory Deficits and Obsessive-Compulsive Behavior in Rats

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Hajheidari Samira; MILADI GORJI HOSSEIN; BIGDELI IMANOLLAH

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Journal Paper

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Journal: Iranian Journal of Psychiatry Year:2017 | Volume:12 | Issue:1 Page(s): 8-14

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Title

Environmental Enrichment Prevents Methamphetamine-Induced Spatial Memory Deficits and Obsessive-Compulsive Behavior in Rats

Author(s)

Hajheidari Samira | MILADI GORJI HOSSEIN | BIGDELI IMANOLLAH | Issue Writer Certificate

Keywords

Environmental Enrichment

Grooming

Methamphetamine

Obsessive-Compulsive Disorder

Spatial Learning and Memory

Abstract

Objective: This study was designed to examine the effect of Environmental Enrichment during Methamphetamine (METH) dependency and withdrawal on Methamphetamine-induced Spatial Learning and Memory deficits and obsessive-compulsive behavior. Method: Adult male Wistar rats (200 ± 10 g) chronically received bi-daily doses of METH (2 mg/kg, sc, with 12 hours intervals) for 14 days. Rats reared in standard (SE) or enriched environment (EE) during the development of dependence on METH and withdrawal. Then, they were tested for Spatial Learning and Memory (the water maze), and obsessive-compulsive behavior as Grooming behavior in METH-withdrawn rats. Results: The results revealed that the Sal/EE and METH/EE rats reared in EE spent more time in the target zone on the water maze and displayed significantly increased proximity to the platform compared to their control groups. METH withdrawn rats reared in EE displayed less Grooming behavior than METH/SE group. Conclusion: Our findings revealed EE ameliorates METH-induced spatial memory deficits and obsessive-compulsive behavior in rats.

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APA: Copy

Hajheidari, Samira, MILADI GORJI, HOSSEIN, & BIGDELI, IMANOLLAH. (2017). Environmental Enrichment Prevents Methamphetamine-Induced Spatial Memory Deficits and Obsessive-Compulsive Behavior in Rats. IRANIAN JOURNAL OF PSYCHIATRY, 12(1), 8-14. SID. https://sid.ir/paper/302423/en

Vancouver: Copy

Hajheidari Samira, MILADI GORJI HOSSEIN, BIGDELI IMANOLLAH. Environmental Enrichment Prevents Methamphetamine-Induced Spatial Memory Deficits and Obsessive-Compulsive Behavior in Rats. IRANIAN JOURNAL OF PSYCHIATRY[Internet]. 2017;12(1):8-14. Available from: https://sid.ir/paper/302423/en

IEEE: Copy

Samira Hajheidari, HOSSEIN MILADI GORJI, and IMANOLLAH BIGDELI, “Environmental Enrichment Prevents Methamphetamine-Induced Spatial Memory Deficits and Obsessive-Compulsive Behavior in Rats,” IRANIAN JOURNAL OF PSYCHIATRY, vol. 12, no. 1, pp. 8–14, 2017, [Online]. Available: https://sid.ir/paper/302423/en

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