Comparison of Saffron and Fluvoxamine in the Treatment of Mild to Moderate Obsessive-Compulsive Disorder: A Double Blind, Randomized Clinical Trial

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ESALATMANESH SOPHIA; Biuseh Mojtaba; NOORBALA AHMAD ALI; MOSTAFAVI SEYED ALI; REZAEI FARZIN; MESGARPOUR BITA; MOHAMMADINEJAD PAYAM; AKHONDZADEH SHAHIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Psychiatry Year:2017 | Volume:12 | Issue:3 Page(s): 154-162

Download Full-Text

View:

153

Download:

150

Cites:

Information Journal Paper

Title

Comparison of Saffron and Fluvoxamine in the Treatment of Mild to Moderate Obsessive-Compulsive Disorder: A Double Blind, Randomized Clinical Trial

Author(s)

Keywords

Crocus sativus

OCD

Saffron

Serotonin

Trial

Abstract

Objective: There are different pathophysiological mechanisms for obsessive-compulsive disorder (OCD) as suggested by the serotonergic, dopaminergic, and glutamatergic hypotheses. The present study aimed at comparing the efficacy and safety of Saffron (stigma of Crocus sativus) and fluvoxamine in the treatment of mild to moderate obsessivecompulsive disorder. Method: In this study, 50 males and females, aged 18 to 60 years, with mild to moderate OCD, participated. The patients were randomly assigned to receive either Saffron (30 mg/day, 15 mg twice a day) or fluvoxamine (100 mg/day) for 10 weeks. Using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the Adverse Event Checklist, we assessed the patients at baseline, and at the second, fourth, sixth, eighth, and tenth week. Finally, the data were analyzed using general linear repeated measures. Results: In this study, 46 patients completed the Trial. General linear repeated measures demonstrated no significant effect for time-treatment interaction on the Y-BOCS total scores [F (2. 42, 106. 87) = 0. 70, P = 0. 52], obsession Y-BOCS subscale scores [F (2. 47, 108. 87) = 0. 77, p = 0. 49], and compulsion Y-BOCS subscale scores [F (2. 18, 96. 06) = 0. 25, P = 0. 79]. Frequency of adverse events was not significantly different between the 2 groups. Conclusion: Our findings suggest that Saffron is as effective as fluvoxamine in the treatment of patients with mild to moderate OCD.

Cites

Herbal Medicine in the Treatment of Obsessive Compulsive Disorder: A Review

References

No record.

Cite

APA: Copy

ESALATMANESH, SOPHIA, Biuseh, Mojtaba, NOORBALA, AHMAD ALI, MOSTAFAVI, SEYED ALI, REZAEI, FARZIN, MESGARPOUR, BITA, MOHAMMADINEJAD, PAYAM, & AKHONDZADEH, SHAHIN. (2017). Comparison of Saffron and Fluvoxamine in the Treatment of Mild to Moderate Obsessive-Compulsive Disorder: A Double Blind, Randomized Clinical Trial. IRANIAN JOURNAL OF PSYCHIATRY, 12(3), 154-162. SID. https://sid.ir/paper/302471/en

Vancouver: Copy

ESALATMANESH SOPHIA, Biuseh Mojtaba, NOORBALA AHMAD ALI, MOSTAFAVI SEYED ALI, REZAEI FARZIN, MESGARPOUR BITA, MOHAMMADINEJAD PAYAM, AKHONDZADEH SHAHIN. Comparison of Saffron and Fluvoxamine in the Treatment of Mild to Moderate Obsessive-Compulsive Disorder: A Double Blind, Randomized Clinical Trial. IRANIAN JOURNAL OF PSYCHIATRY[Internet]. 2017;12(3):154-162. Available from: https://sid.ir/paper/302471/en

IEEE: Copy

SOPHIA ESALATMANESH, Mojtaba Biuseh, AHMAD ALI NOORBALA, SEYED ALI MOSTAFAVI, FARZIN REZAEI, BITA MESGARPOUR, PAYAM MOHAMMADINEJAD, and SHAHIN AKHONDZADEH, “Comparison of Saffron and Fluvoxamine in the Treatment of Mild to Moderate Obsessive-Compulsive Disorder: A Double Blind, Randomized Clinical Trial,” IRANIAN JOURNAL OF PSYCHIATRY, vol. 12, no. 3, pp. 154–162, 2017, [Online]. Available: https://sid.ir/paper/302471/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops