STUDY ON MRI CHANGES IN PHENYLKETONURIA IN PATIENTS REFERRED TO MOFID HOSPITAL/ IRAN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KARIMZADEH PARVENEH; AHMADABADI FARZAD; JAFARI NARJES; SHARIATMADARI FAKHREDDIN; NEMATI HAMID; AHADI ADEL; KARIMI DARDASHTI SANAZ; MIRZARAHIMI MEHRDAD; DASTBORHAN ZAHRA; ZARE NOGHABI JAVAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Child Neurology Year:2014 | Volume:8 | Issue:2 Page(s): 53-56

Download Full-Text

View:

311

Download:

Cites:

Information Journal Paper

Title

STUDY ON MRI CHANGES IN PHENYLKETONURIA IN PATIENTS REFERRED TO MOFID HOSPITAL/ IRAN

Author(s)

Keywords

PHENYLKETONURIA

MRI

THOMPSON SCORE

Abstract

Objective: PHENYLKETONURIA is one of the most common metabolic disorders and the first known cause of mental retardation in pediatrics. As Screening for PHENYLKETONURIA (PKU) is not a routine neurometabolic screening test for neonates in Iran, many PKU cases may be diagnosed after developing the clinical symptoms. One of the findings of PKU is myelination disorders, which is seen as hypersignal regions in T2-weighted (T2W) and FLAIR sequences of brain MRI. The aim of our study was to assess MRI changes in PKU patients referred to Mofid Children’s Hospital, 2010-2011.Materials & Methods: We studied all PKU cases referred to our clinic as a referral neurometabolic center in Iran for brain MRI and assessed the phenylalanine level at the time of Imaging. The mean phenylalanine level (in one year), clinical manifestations, and MRI pattern based on Thompson scoring, were evaluated.Results: The mean age of our study group was 155±99 months and the mean diagnosis age was 37±27.85 months. There were 15 patients with positive and 15 with negative family history. The mean phenylalanine level at the time of imaging was 9.75±6.28 and the mean 1 year phenylalanine level was 10.28±4.82. Seventy percent of our patients had MRI involvement, in whom 20% showed atrophic changes, in addition to white matter involvement. Based on modified Thompson scoring, the score for our study group was 4.84. The maximum involvement in MRI was in occipital region, followed by parietal, frontal, and temporal zones. There was not any correlation between MRI score and patients’ age. But we found significant relationship between MRI score and the age of regimen cessation. No correlation was seen between phenylalanine level (at the time of Imaging) and MRI score. But there was a relationship between mean 1 year phenylalanine level and MRI score.Conclusion: According to the results of this study, brain MRI and white matter involvement can be used for evaluation of long-term control of phenylalanine level in PKU cases.

Cites

No record.

References

No record.

Cite

APA: Copy

KARIMZADEH, PARVENEH, AHMADABADI, FARZAD, JAFARI, NARJES, SHARIATMADARI, FAKHREDDIN, NEMATI, HAMID, AHADI, ADEL, KARIMI DARDASHTI, SANAZ, MIRZARAHIMI, MEHRDAD, DASTBORHAN, ZAHRA, & ZARE NOGHABI, JAVAD. (2014). STUDY ON MRI CHANGES IN PHENYLKETONURIA IN PATIENTS REFERRED TO MOFID HOSPITAL/ IRAN. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), 8(2), 53-56. SID. https://sid.ir/paper/303397/en

Vancouver: Copy

KARIMZADEH PARVENEH, AHMADABADI FARZAD, JAFARI NARJES, SHARIATMADARI FAKHREDDIN, NEMATI HAMID, AHADI ADEL, KARIMI DARDASHTI SANAZ, MIRZARAHIMI MEHRDAD, DASTBORHAN ZAHRA, ZARE NOGHABI JAVAD. STUDY ON MRI CHANGES IN PHENYLKETONURIA IN PATIENTS REFERRED TO MOFID HOSPITAL/ IRAN. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)[Internet]. 2014;8(2):53-56. Available from: https://sid.ir/paper/303397/en

IEEE: Copy

PARVENEH KARIMZADEH, FARZAD AHMADABADI, NARJES JAFARI, FAKHREDDIN SHARIATMADARI, HAMID NEMATI, ADEL AHADI, SANAZ KARIMI DARDASHTI, MEHRDAD MIRZARAHIMI, ZAHRA DASTBORHAN, and JAVAD ZARE NOGHABI, “STUDY ON MRI CHANGES IN PHENYLKETONURIA IN PATIENTS REFERRED TO MOFID HOSPITAL/ IRAN,” IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), vol. 8, no. 2, pp. 53–56, 2014, [Online]. Available: https://sid.ir/paper/303397/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops