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Information Journal Paper

Title

ASSOCIATION OF 25-HYDROXYVITAMIN D DEFICIENCY IN PEDIATRIC EPILEPTIC PATIENTS

Pages

  48-56

Abstract

 Objective EPILEPSY is a chronic neurological disorder requiring long-term therapy using antiepileptic medications. Reports have incriminated long-term antiepileptic drugs use in deficiency of vitamin D and bone diseases in all age groups. We aimed to investigate the association between serum 25-HYDROXYVITAMIN D levels and pediatric EPILEPSY in INDIAN PATIENTS.Materials & Methods We prospectively recruited 100 pediatric EPILEPSY patients, on monotherapy for minimum one-year duration, and 50 age and sex matched controls. This study was carried out at Yashoda Hospital, India from 2011-2014. All cases and controls underwent tests for serum 25-HYDROXYVITAMIN D, ALKALINE PHOSPHATASE, serum CALCIUM and phosphorus levels.Results Patients with 25-HYDROXYVITAMIN D deficiency were significantly higher among cases (45%) than controls (24%). Mean ALKALINE PHOSPHATASE was significantly higher in cases and mean serum CALCIUM was significantly lower (8.3±1.5) in cases. Amongst antiepileptic drugs, carbamazepine and sodium valproate were significantly associated with 25-HYDROXYVITAMIN D deficiency. Risk of vitamin D deficiency was highest with sodium valproate usage (odds: 4.0; 95%CI 1.4-11.6) followed by carbamazepine use (odds: 2.7; 95%CI 1.0-6.8). After adjustment using multiple logistic regression, antiepileptic drugs showed independent association with 25-HYDROXYVITAMIN D deficiency (odds: 2.2; 95%CI 0.9-4.5).Conclusion 25-HYDROXYVITAMIN D deficiency was significantly associated with use of carbamazepine and sodium valproate in pediatric EPILEPSY.

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    APA: Copy

    CHAUDHURI, JAYDIP RAY, Mridula, Kandadai Rukmini, RATHNAKISHORE, Chakrala, BALARAJU, Banda, & BANDARU, VCS Srinivasarao. (2017). ASSOCIATION OF 25-HYDROXYVITAMIN D DEFICIENCY IN PEDIATRIC EPILEPTIC PATIENTS. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), 11(2), 48-56. SID. https://sid.ir/paper/303531/en

    Vancouver: Copy

    CHAUDHURI JAYDIP RAY, Mridula Kandadai Rukmini, RATHNAKISHORE Chakrala, BALARAJU Banda, BANDARU VCS Srinivasarao. ASSOCIATION OF 25-HYDROXYVITAMIN D DEFICIENCY IN PEDIATRIC EPILEPTIC PATIENTS. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)[Internet]. 2017;11(2):48-56. Available from: https://sid.ir/paper/303531/en

    IEEE: Copy

    JAYDIP RAY CHAUDHURI, Kandadai Rukmini Mridula, Chakrala RATHNAKISHORE, Banda BALARAJU, and VCS Srinivasarao BANDARU, “ASSOCIATION OF 25-HYDROXYVITAMIN D DEFICIENCY IN PEDIATRIC EPILEPTIC PATIENTS,” IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), vol. 11, no. 2, pp. 48–56, 2017, [Online]. Available: https://sid.ir/paper/303531/en

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