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Information Journal Paper

Title

THERAPEUTIC EFFECTS OF ADRENOCORTICOTROPIC HORMONE ACTH IN CHILDREN WITH SEVERELY INTRACTABLE SEIZURE

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Abstract

 ObjectiveTreatment of INTRACTABLE SEIZURES other than spasms is difficult and controversial.There are few studies on efficacy of adrenocorticotropic hormone (ACTH) intreatment of patients with INTRACTABLE seizure.Materials & MethodsTwenty-five patients with INTRACTABLE seizure other than spasm including 14boys and 11 girls with median age of 58 months referred to university clinicsof Pediatric Neurology in Isfahan, Iran, during 2014-2015 were prospectivelyinvestigated. ACTH was administrated according to our protocol. All caseswere followed regularly and assessed for response to treatment and probableside effects, 3 wk after beginning of ACTH therapy and three months after theACTH therapy. EEG finding were recorded before and three months after theend of ACTH therapy. Statistical analysis using Freidman test and Wilcoxonsigned – rank test were performed in order to compare seizure frequency andEEG changes, respectively.resultsMean A significant reduction (>80%) in seizure frequency in 11 cases (44%)and moderate reduction (50%-80%) in 7 (28%) after 3 wk of ACTH therapy.Despite initial positive response, recurrence of seizure was observed in 7 out of18 cases with favorable initial response within 3 months after ACTH therapycessation. The comparison of EEG finding before and 3 months after ACTHtherapy using Wilcoxon signed – rank test showed significant differences.ConclusionACTH therapy may be useful in treatment of CHILDREN with INTRACTABLE SEIZURESwho are resistant to usual antiepileptic drugs. However further studies shouldbe performed to determine the long-term efficacy of ACTH in treatment ofintractable seizure.

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    APA: Copy

    NASIRI, JAFAR, Sarajan, Azam, SALARI, MEHRI, & SEDGHI, MARYAM. (2017). THERAPEUTIC EFFECTS OF ADRENOCORTICOTROPIC HORMONE ACTH IN CHILDREN WITH SEVERELY INTRACTABLE SEIZURE. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), 11(3), 0-0. SID. https://sid.ir/paper/303548/en

    Vancouver: Copy

    NASIRI JAFAR, Sarajan Azam, SALARI MEHRI, SEDGHI MARYAM. THERAPEUTIC EFFECTS OF ADRENOCORTICOTROPIC HORMONE ACTH IN CHILDREN WITH SEVERELY INTRACTABLE SEIZURE. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)[Internet]. 2017;11(3):0-0. Available from: https://sid.ir/paper/303548/en

    IEEE: Copy

    JAFAR NASIRI, Azam Sarajan, MEHRI SALARI, and MARYAM SEDGHI, “THERAPEUTIC EFFECTS OF ADRENOCORTICOTROPIC HORMONE ACTH IN CHILDREN WITH SEVERELY INTRACTABLE SEIZURE,” IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), vol. 11, no. 3, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/303548/en

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