THE EFFECT OF FLUOXETINE ON SPERMATOGENESIS AND SPERMATOGONIAL STEM CELLS SELF-RENEWAL IN ADULT MALE RATS

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AKBARI HANIYEH; HASANZADEH SHAPOUR; SHALIZAR JALALI ALI; MALEKINEJAD HASSAN

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Journal: DANESHVAR MEDICINE Year:2018 | Volume:25 | Issue:132 Page(s): 1-6

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Title

THE EFFECT OF FLUOXETINE ON SPERMATOGENESIS AND SPERMATOGONIAL STEM CELLS SELF-RENEWAL IN ADULT MALE RATS

Author(s)

AKBARI HANIYEH | HASANZADEH SHAPOUR | SHALIZAR JALALI ALI | MALEKINEJAD HASSAN | Issue Writer Certificate

Keywords

FLUOXETINEQ1

SELF-RENEWALQ1

SPERMATOGONIAL STEM CELLSQ1

SPERMATOGENESISQ2

RATQ2

GFR$#945;1Q1

Abstract

Background and Objective: FLUOXETINE (FLX) application as a selective serotonin reuptake inhibitor (SSRI) drug that accompanies side effects including reproductive dysfunctions. The current study was designed to explore the effects of FLX on RAT SPERMATOGENESIS as well as SPERMATOGONIAL STEM CELLS SELF-RENEWAL through evaluation of glial cell line-derived neurotrophic factor family receptor alpha-1 (GFRa1) expression at mRNA level in testicular tissue.Materials and Methods: Adult male Wistar RATs were randomly allocated into experimental and control groups. The experimental group was subdivided into two groups which received 5 mg/kg/day and 10 mg/kg/day of FLX orally for 48 days.Testicular tissue samples were collected 24 hours after the last treatment and histological assessments and reverse transcription polymerase chain reaction were done to analyze SPERMATOGENESIS and mRNA expression of GFRα1, respectively.Results: Treatment with FLX caused spermatozoa maturation arrest in a dose-dependent manner as was evident by significant decreases in spermatogenic indices. Moreover, FLX administration at a dose of 10 mg/kg/day resulted in significant reduction in mRNA expression of GFRα1 in testicular tissue.Conclusion: These findings suggest that FLX induces male reproductive toxicities via disruption of SPERMATOGONIAL STEM CELLS SELF-RENEWAL, bringing about the necessity of more researches about the precise mechanisms of SSRI antidepressants-induced spermatogenic failures.

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APA: Copy

AKBARI, HANIYEH, HASANZADEH, SHAPOUR, SHALIZAR JALALI, ALI, & MALEKINEJAD, HASSAN. (2018). THE EFFECT OF FLUOXETINE ON SPERMATOGENESIS AND SPERMATOGONIAL STEM CELLS SELF-RENEWAL IN ADULT MALE RATS. DANESHVAR MEDICINE, 25(132 ), 1-6. SID. https://sid.ir/paper/30358/en

Vancouver: Copy

AKBARI HANIYEH, HASANZADEH SHAPOUR, SHALIZAR JALALI ALI, MALEKINEJAD HASSAN. THE EFFECT OF FLUOXETINE ON SPERMATOGENESIS AND SPERMATOGONIAL STEM CELLS SELF-RENEWAL IN ADULT MALE RATS. DANESHVAR MEDICINE[Internet]. 2018;25(132 ):1-6. Available from: https://sid.ir/paper/30358/en

IEEE: Copy

HANIYEH AKBARI, SHAPOUR HASANZADEH, ALI SHALIZAR JALALI, and HASSAN MALEKINEJAD, “THE EFFECT OF FLUOXETINE ON SPERMATOGENESIS AND SPERMATOGONIAL STEM CELLS SELF-RENEWAL IN ADULT MALE RATS,” DANESHVAR MEDICINE, vol. 25, no. 132 , pp. 1–6, 2018, [Online]. Available: https://sid.ir/paper/30358/en

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