مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

DUCHENNE MUSCULAR DYSTROPHY (DMD) PROTEIN-PROTEIN INTERACTION MAPPING

Pages

  7-14

Abstract

 Objective: Duchenne muscular dystrophy (DMD) is one of the mortal diseases, subjected to study in terms of molecular investigation. In this study, the protein interaction map of this muscle-wasting condition was generated to gain a better knowledge of interactome profile of DMD.Materials & Methods: Applying Cytoscape and String Database, the PROTEIN-PROTEIN INTERACTION NETWORK was constructed and the gene ontology of the constructed network was analyzed for biological process, molecular function, and cellular component annotations.Results: Among 100 proteins related to DMD, dystrophin, utrophin, caveolin 3, and myogenic differentiation 1 play key roles in DMD network. In addition, the gene ontology analysis showed that regulation processes, kinase activity, and sarcoplasmic reticulum were the highlighted biological processes, molecular function, and cell component enrichments respectively for the proteins related to DMD.Conclusion: The central proteins and the enriched ontologies can be suggested as possible prominent agents in DMD; however, the validation studies may be required.

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  • Cite

    APA: Copy

    REZAEI TAVIRANI, MOSTAFA, OKHOVATIAN, FARSHAD, ZAMANIAN AZODI, MONA, & REZAEI TAVIRANI, MAJID. (2017). DUCHENNE MUSCULAR DYSTROPHY (DMD) PROTEIN-PROTEIN INTERACTION MAPPING. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), 11(4), 7-14. SID. https://sid.ir/paper/303610/en

    Vancouver: Copy

    REZAEI TAVIRANI MOSTAFA, OKHOVATIAN FARSHAD, ZAMANIAN AZODI MONA, REZAEI TAVIRANI MAJID. DUCHENNE MUSCULAR DYSTROPHY (DMD) PROTEIN-PROTEIN INTERACTION MAPPING. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)[Internet]. 2017;11(4):7-14. Available from: https://sid.ir/paper/303610/en

    IEEE: Copy

    MOSTAFA REZAEI TAVIRANI, FARSHAD OKHOVATIAN, MONA ZAMANIAN AZODI, and MAJID REZAEI TAVIRANI, “DUCHENNE MUSCULAR DYSTROPHY (DMD) PROTEIN-PROTEIN INTERACTION MAPPING,” IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), vol. 11, no. 4, pp. 7–14, 2017, [Online]. Available: https://sid.ir/paper/303610/en

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