THE EFFECT OF CHOLESTASIS AND NEUROAID TREATMENT ON BCL-XL GENE EXPRESSION IN HIPPOCAMPUS OF MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOLAEI PEZHMAN; NASEHI MOHAMMAD; HASHEMI MEHRDAD

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: DANESHVAR MEDICINE Year:2018 | Volume:25 | Issue:132 Page(s): 7-14

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

952

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF CHOLESTASIS AND NEUROAID TREATMENT ON BCL-XL GENE EXPRESSION IN HIPPOCAMPUS OF MALE RATS

Author(s)

MOLAEI PEZHMAN | NASEHI MOHAMMAD | HASHEMI MEHRDAD | Issue Writer Certificate

Keywords

CHOLESTASISQ2

APOPTOSISQ1

BCL-XLQ1

NEUROAIDQ1

HIPPOCAMPUSQ2

Abstract

Background and Objective: CHOLESTASIS is bile duct obstruction with accumulation of toxic bile acids in liver and circulatory systems and increased toxicity in hepatocytes. Some studies have shown that CHOLESTASIS induces spatial memory deficit. HIPPOCAMPUS plays an important role in this process. In this research, the effect of CHOLESTASIS on expression of BCL-XL (B-cell lymphomaextra large as genes in APOPTOSIS further) in HIPPOCAMPUS of male rat was assessed. Moreover, the preventive effect of NEUROAID (MLC901) on abovementioned changes regarding gene expression was also evaluated.Materials and Methods: This project was done on 16 rats weighing 220-240 g, which were divided into three main groups including control, sham and BDL (Bile Duct Ligation). Thereafter, HIPPOCAMPUS region was extracted and the expression level of genes were assessment by Real-Time PCR. Results were analyzed using one-way ANOVA followed by a Tukey test. Significant level was 0.05.Results: The results of sham-NeuroAID & BDL-NeuroAID groups indicate that NEUROAID significantly increases the expression level of BCL-XL gene in comparison with control group. In addition, there was no significant change for subsequent effect of CHOLESTASIS in the expression level of BCL-XL gene in BDL group.Conclusion: Results of the current study indicates that NEUROAID can alter negative effect of CHOLESTASIS by decreasing APOPTOSIS phenomenon.

Cites

No record.

References

NEUROGENESIS IN THE STRIATUM OF THE ADULT HUMAN BRAIN

Cite

APA: Copy

MOLAEI, PEZHMAN, NASEHI, MOHAMMAD, & HASHEMI, MEHRDAD. (2018). THE EFFECT OF CHOLESTASIS AND NEUROAID TREATMENT ON BCL-XL GENE EXPRESSION IN HIPPOCAMPUS OF MALE RATS. DANESHVAR MEDICINE, 25(132 ), 7-14. SID. https://sid.ir/paper/30364/en

Vancouver: Copy

MOLAEI PEZHMAN, NASEHI MOHAMMAD, HASHEMI MEHRDAD. THE EFFECT OF CHOLESTASIS AND NEUROAID TREATMENT ON BCL-XL GENE EXPRESSION IN HIPPOCAMPUS OF MALE RATS. DANESHVAR MEDICINE[Internet]. 2018;25(132 ):7-14. Available from: https://sid.ir/paper/30364/en

IEEE: Copy

PEZHMAN MOLAEI, MOHAMMAD NASEHI, and MEHRDAD HASHEMI, “THE EFFECT OF CHOLESTASIS AND NEUROAID TREATMENT ON BCL-XL GENE EXPRESSION IN HIPPOCAMPUS OF MALE RATS,” DANESHVAR MEDICINE, vol. 25, no. 132 , pp. 7–14, 2018, [Online]. Available: https://sid.ir/paper/30364/en

Related Journal Papers