PATTERN OF ANTIBIOTIC SUSCEPTIBILITY AND DETECTION OF CTX-M-TYPE EXTENDED SPECTRUM BETA-LACTAMASES (ESBLS) IN URINARY ISOLATES OF KLEBSIELLA PNEUMONIAE IN MASHHAD

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NAKHAEE MOGHADAM MAHBOOBEH; NADERIFAR SAHAR; ZOLFAGHARI MOHAMMAD REZA; AMEL JAMEHDAR SAEID; HASHEMI MEHRDAD

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2012 | Volume:19 | Issue:96 Page(s): 29-36

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Title

PATTERN OF ANTIBIOTIC SUSCEPTIBILITY AND DETECTION OF CTX-M-TYPE EXTENDED SPECTRUM BETA-LACTAMASES (ESBLS) IN URINARY ISOLATES OF KLEBSIELLA PNEUMONIAE IN MASHHAD

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Keywords

KLEBSIELLA PNEUMONIAEQ1

ANTIBIOTIC SENSITIVITYQ2

EXTENDED SPECTRUM BETA-LACTAMASESQ2

CTX-M TYPEQ2

Abstract

Background and Objective: EXTENDED SPECTRUM BETA-LACTAMASES (ESBLs) are defined as enzymes capable of hydrolyzing oxyiminocephalosporins.Selective pressure of overuse of new antibiotics may be associated with emergence of new types of beta- lactamases. The aim of this study was to identify urinary isolates of CTX-M ESBL-producing KLEBSIELLA PNEUMONIAE and to detect their pattern of antibiotic susceptibility Materials and Methods: Bacteria were isolated and identified from the urine samples sent to laboratories of two hospitals in Mashhad in 2010.Isolates were then tested for antimicrobial susceptibility by disc diffusion and examined for beta-lactamase production by double disk approximation test and CLSI (Clinical and Laboratory Standards Institute) confirmatory test. The bla CTX-M genes were detected by polymerase chain reaction using specific primer.Results: Out of 100 studied urinary specimens, 19 bacteria were K.pneumonia, of which 47.4% were ESBL producer and all were positive for blaCTX-M gene. A large percentage of ESBL-producing isolates compared to ESBL-non producers were resistant to co-trimoxazole, gentamicin, and nalidixic acid and the difference for gentamicin was significant.Conclusion: Due to relatively high prevalence of ESBL-producing bacteria in the studied population, screening of infections caused by these bacteria would be important for appropriate treatment.

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APA: Copy

NAKHAEE MOGHADAM, MAHBOOBEH, NADERIFAR, SAHAR, ZOLFAGHARI, MOHAMMAD REZA, AMEL JAMEHDAR, SAEID, & HASHEMI, MEHRDAD. (2012). PATTERN OF ANTIBIOTIC SUSCEPTIBILITY AND DETECTION OF CTX-M-TYPE EXTENDED SPECTRUM BETA-LACTAMASES (ESBLS) IN URINARY ISOLATES OF KLEBSIELLA PNEUMONIAE IN MASHHAD. DANESHVAR MEDICINE, 19(96), 29-36. SID. https://sid.ir/paper/30381/en

Vancouver: Copy

NAKHAEE MOGHADAM MAHBOOBEH, NADERIFAR SAHAR, ZOLFAGHARI MOHAMMAD REZA, AMEL JAMEHDAR SAEID, HASHEMI MEHRDAD. PATTERN OF ANTIBIOTIC SUSCEPTIBILITY AND DETECTION OF CTX-M-TYPE EXTENDED SPECTRUM BETA-LACTAMASES (ESBLS) IN URINARY ISOLATES OF KLEBSIELLA PNEUMONIAE IN MASHHAD. DANESHVAR MEDICINE[Internet]. 2012;19(96):29-36. Available from: https://sid.ir/paper/30381/en

IEEE: Copy

MAHBOOBEH NAKHAEE MOGHADAM, SAHAR NADERIFAR, MOHAMMAD REZA ZOLFAGHARI, SAEID AMEL JAMEHDAR, and MEHRDAD HASHEMI, “PATTERN OF ANTIBIOTIC SUSCEPTIBILITY AND DETECTION OF CTX-M-TYPE EXTENDED SPECTRUM BETA-LACTAMASES (ESBLS) IN URINARY ISOLATES OF KLEBSIELLA PNEUMONIAE IN MASHHAD,” DANESHVAR MEDICINE, vol. 19, no. 96, pp. 29–36, 2012, [Online]. Available: https://sid.ir/paper/30381/en

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