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Information Journal Paper

Title

ALLELIC DIMORPHISM OF THE PLASMODIUM FALCIPARUM ERYTHROCYTE BINDING ANTIGEN-175 (EBA-175) GENE IN THE SOUTHEAST OF IRAN

Pages

  17-22

Abstract

 Background: The erythrocyte binding antigen 175 kDa (EBA-175) gene is located on chromosome 7. It encodes protein that binds to specific receptor glycophorin A on the erythrocyte surface during invasion. It has a dimorphic nature (FCR3 and CAMP). This study was designed to determine the distribution of EBA-175 alleles of PLASMODIUM FALCIPARUM in the southeast of IRAN.Methods: We used the nested PCR method with specific primers, which improves the two fragments of the EBA-175 gene. Sixty eight microscopically positive blood samples were collected from the infected falciparum MALARIA subjects in the southeast of IRAN.Results: In this study which marks the first one in IRAN, CAMP strains (714 bp) and FCR-3 strains (795 bp) were found in 14 (37.8%) and 23 (62.2%) in the originally IRANian subjects and in 10 (32.3%) and 19 (61.3%) Pakistani infected migrants respectively. Two migrant cases (6.4%) had mix CAMP/FCR-3 infection.Conclusion: The two fragments of dimorphic EBA-175 gene were observed and the FCR-3 allele was more prevalent in IRAN. There was no significant correlation between one of the EBA-175 alleles and the subject group in the mentioned region. This distributional pattern should be considered in designing to control P. falciparum MALARIA in the region.

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    APA: Copy

    HEYDARI, A., KESHAVARZ, H., DITTRICH, S., & JELINEK, T.. (2009). ALLELIC DIMORPHISM OF THE PLASMODIUM FALCIPARUM ERYTHROCYTE BINDING ANTIGEN-175 (EBA-175) GENE IN THE SOUTHEAST OF IRAN. IRANIAN JOURNAL OF PARASITOLOGY, 4(2), 17-22. SID. https://sid.ir/paper/303875/en

    Vancouver: Copy

    HEYDARI A., KESHAVARZ H., DITTRICH S., JELINEK T.. ALLELIC DIMORPHISM OF THE PLASMODIUM FALCIPARUM ERYTHROCYTE BINDING ANTIGEN-175 (EBA-175) GENE IN THE SOUTHEAST OF IRAN. IRANIAN JOURNAL OF PARASITOLOGY[Internet]. 2009;4(2):17-22. Available from: https://sid.ir/paper/303875/en

    IEEE: Copy

    A. HEYDARI, H. KESHAVARZ, S. DITTRICH, and T. JELINEK, “ALLELIC DIMORPHISM OF THE PLASMODIUM FALCIPARUM ERYTHROCYTE BINDING ANTIGEN-175 (EBA-175) GENE IN THE SOUTHEAST OF IRAN,” IRANIAN JOURNAL OF PARASITOLOGY, vol. 4, no. 2, pp. 17–22, 2009, [Online]. Available: https://sid.ir/paper/303875/en

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