IN VITRO INHIBITORY EFFECT OF BERBERIS VULGARIS (BERBERIDACEAE) AND ITS MAIN COMPONENT, BERBERINE AGAINST DIFFERENT LEISHMANIA SPECIES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MAHMOUDVAND HOSSEIN; SHARIFIFAR FARIBA; SHARIFI IRAJ; EZATPOUR BEHROUZ; FASIHI HARANDI MAJID; MAKKI MAHSA SADAT; ZIA ALI NASER; JAHANBAKHSH SAREH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Parasitology Year:2014 | Volume:9 | Issue:1 Page(s): 28-36

Download Full-Text

View:

392

Download:

211

Cites:

Information Journal Paper

Title

IN VITRO INHIBITORY EFFECT OF BERBERIS VULGARIS (BERBERIDACEAE) AND ITS MAIN COMPONENT, BERBERINE AGAINST DIFFERENT LEISHMANIA SPECIES

Author(s)

Keywords

BERBERIS VULGARIS

BERBERINE

LEISHMANIA INFANTUM

LEISHMANIA TROPICA

IN VITRO

Abstract

Background: Leishmaniasis has been identified as a major public health problem in tropical and subtropical countries. The present study was aimed to investigate antileishmanial effects of various extracts of BERBERIS VULGARIS also its active compoenent, BERBERINE against LEISHMANIA TROPICA and L. infantum species on IN VITRO experiments.Methods: In this study IN VITRO antileishmanial activity of various extracts of B. vulgaris also its active compoenent, BERBERINE against promastigote and amastigote stages of L. tropica and L. infantum was evaluated, using MTT assay and in a macro-phage model, respectively. Furthermore, infectivity rate and cytotoxicity effects of B. vulgaris and BERBERINE in murine macrophage cells were investigated.Results: The findings of optical density (OD) and IC50 indicated that B. vulgaris particulary BERBERINE significantly (P<0.05) inhibited the growth rate of promastigote stage of L. tropica and L. infantum in comparison to meglumine antimoniate (MA). In addition, B. vulgaris and BERBERINE significantly (P<0.05) decreased the mean number of amastigotes in each macrophage as compared with positive control. In the evaluation of cytotoxicity effects, it could be observed that BERBERINE as compared with B. vulgaris exhibited more cytotoxicity against murine macrophages. Results also showed that when parasites were preincubated with B. vulgaris their ability to infect murine macrophages was significantly decreased.Conclusion: B. vulgaris particularly BERBERINE exhibited potent IN VITRO leishmanicidal effects against L. tropica and L. infantum. Further works are required to evaluate the antileishmanial effects of B. vulgaris on Leishmania species using clinical settings.

Cites

No record.

References

No record.

Cite

APA: Copy

MAHMOUDVAND, HOSSEIN, SHARIFIFAR, FARIBA, SHARIFI, IRAJ, EZATPOUR, BEHROUZ, FASIHI HARANDI, MAJID, MAKKI, MAHSA SADAT, ZIA ALI, NASER, & JAHANBAKHSH, SAREH. (2014). IN VITRO INHIBITORY EFFECT OF BERBERIS VULGARIS (BERBERIDACEAE) AND ITS MAIN COMPONENT, BERBERINE AGAINST DIFFERENT LEISHMANIA SPECIES. IRANIAN JOURNAL OF PARASITOLOGY, 9(1), 28-36. SID. https://sid.ir/paper/304044/en

Vancouver: Copy

MAHMOUDVAND HOSSEIN, SHARIFIFAR FARIBA, SHARIFI IRAJ, EZATPOUR BEHROUZ, FASIHI HARANDI MAJID, MAKKI MAHSA SADAT, ZIA ALI NASER, JAHANBAKHSH SAREH. IN VITRO INHIBITORY EFFECT OF BERBERIS VULGARIS (BERBERIDACEAE) AND ITS MAIN COMPONENT, BERBERINE AGAINST DIFFERENT LEISHMANIA SPECIES. IRANIAN JOURNAL OF PARASITOLOGY[Internet]. 2014;9(1):28-36. Available from: https://sid.ir/paper/304044/en

IEEE: Copy

HOSSEIN MAHMOUDVAND, FARIBA SHARIFIFAR, IRAJ SHARIFI, BEHROUZ EZATPOUR, MAJID FASIHI HARANDI, MAHSA SADAT MAKKI, NASER ZIA ALI, and SAREH JAHANBAKHSH, “IN VITRO INHIBITORY EFFECT OF BERBERIS VULGARIS (BERBERIDACEAE) AND ITS MAIN COMPONENT, BERBERINE AGAINST DIFFERENT LEISHMANIA SPECIES,” IRANIAN JOURNAL OF PARASITOLOGY, vol. 9, no. 1, pp. 28–36, 2014, [Online]. Available: https://sid.ir/paper/304044/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops