Immunogenicity of Multi-epitope Vaccine Candidate against Toxoplasma gondii Infection in BALB/c Mice

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HAJISSA Khalid; ZAKARIA Robaiza; SUPPIAN Rapeah; MOHAMED Zeehaida

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PARASITOLOGY Year:2018 | Volume:13 | Issue:2 Page(s): 215-224

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Information Journal Paper

Title

Immunogenicity of Multi-epitope Vaccine Candidate against Toxoplasma gondii Infection in BALB/c Mice

Author(s)

HAJISSA Khalid | ZAKARIA Robaiza | SUPPIAN Rapeah | MOHAMED Zeehaida | Issue Writer Certificate

Keywords

Toxoplasma gondii

Multiepitope peptide

SAG1

GRA2

GRA7

Vaccine

Abstract

Background: Toxoplasma gondii is a widely prevalent intracellular protozoan parasite which causes serious clinical and veterinary problems. Development of an effective Vaccine for controlling toxoplasmosis is an extremely important aim. In the present study, the protective efficacy of recombinant multiepitope antigen (USM. TOXO1) expressing nine potential epitopes identified from SAG1, GRA2, and GRA7 of Toxoplasma gondii was evaluated in BALB/c mice. Methods: Mice were immunized subcutaneously with three doses of USM. TOXO1 antigen (10 μ g/ml). Following the immunization, the IgG antibody, IgG subclass, IFN-γ and IL-4 production were evaluated using ELISA, the study was conducted at Animal Research and Service Center (ARASC), USM Health Campus in 2016. Results: Mice immunized with USM. TOXO1 significantly induced a mixed Th1/Th2 response polarized toward the IgG1 antibody isotype. While the cytokine analysis revealed a significant release of IFN-γ cytokines. Conclusion: USM. TOXO1 is a potential Vaccine candidate that elicits strong immunity in BALB/c mice. The proven immunogenicity of the generated antigen can serve as a premise for further use of epitope-based Vaccine in the immunoprevention of human and animal toxoplasmosis.

Cites

Construction of A Synthetic Gene Encoding the Multi-Epitope of Toxoplasma gondii and Demonstration of the Relevant Recombinant Protein Production: A Vaccine Candidate

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APA: Copy

HAJISSA, Khalid, ZAKARIA, Robaiza, SUPPIAN, Rapeah, & MOHAMED, Zeehaida. (2018). Immunogenicity of Multi-epitope Vaccine Candidate against Toxoplasma gondii Infection in BALB/c Mice. IRANIAN JOURNAL OF PARASITOLOGY, 13(2), 215-224. SID. https://sid.ir/paper/304147/en

Vancouver: Copy

HAJISSA Khalid, ZAKARIA Robaiza, SUPPIAN Rapeah, MOHAMED Zeehaida. Immunogenicity of Multi-epitope Vaccine Candidate against Toxoplasma gondii Infection in BALB/c Mice. IRANIAN JOURNAL OF PARASITOLOGY[Internet]. 2018;13(2):215-224. Available from: https://sid.ir/paper/304147/en

IEEE: Copy

Khalid HAJISSA, Robaiza ZAKARIA, Rapeah SUPPIAN, and Zeehaida MOHAMED, “Immunogenicity of Multi-epitope Vaccine Candidate against Toxoplasma gondii Infection in BALB/c Mice,” IRANIAN JOURNAL OF PARASITOLOGY, vol. 13, no. 2, pp. 215–224, 2018, [Online]. Available: https://sid.ir/paper/304147/en

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