C677T AND A1298C MUTATIONS IN THE METHYLENETETRAHYDROFOLATE REDUCTASE GENE IN PATIENTS WITH RECURRENT ABORTION FROM THE IRANIAN AZERI TURKISH

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BAGHERI MORTEZA; ABDIRAD I.; OMRANI M.D.; NAN BAKHSH F.

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Journal: International Journal of Fertility & Sterility Year:2010 | Volume:4 | Issue:3 Page(s): 134-139

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Information Journal Paper

Title

C677T AND A1298C MUTATIONS IN THE METHYLENETETRAHYDROFOLATE REDUCTASE GENE IN PATIENTS WITH RECURRENT ABORTION FROM THE IRANIAN AZERI TURKISH

Author(s)

BAGHERI MORTEZA | ABDIRAD I. | OMRANI M.D. | NAN BAKHSH F. | Issue Writer Certificate

Keywords

MTHFR

PREGNANCY

RECURRENT ABORTION

Abstract

Background: To assess whether the C677T and A1298C mutations in the methylenetetrahydrofolate reductase (MTHER) gene are associated with RECURRENT ABORTION (RA), we determined the frequencies of the T677 and C1298 mutations in patients and controls.Materials and Methods: Mutations were determined by a RFLP-PCR method in 53 patients and 61 matched controls.Results: The frequencies of T alleles were 0.26 in patients and 0.29 in controls. The frequencies of C/C, T/C and T/T genotypes were 34 (55.7%), 22 (36.1%) and 5 (8.2%) in patients, and 27 (50.9%), 21 (39.6%) and 5 (9.43%) in controls. The C allele frequencies were 0.38 in patients and controls. C/C, A/C and A/A genotype distributions were 9 (14.8%), 28 (45.9%) and 24 (39.3%) in patients, and 8 (15.1%), 24 (45.3%) and 21 (39.6%) in controls.Conclusion: There were no significant differences between patients and controls concerning the T677 and C1298 mutations.

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APA: Copy

BAGHERI, MORTEZA, ABDIRAD, I., OMRANI, M.D., & NAN BAKHSH, F.. (2010). C677T AND A1298C MUTATIONS IN THE METHYLENETETRAHYDROFOLATE REDUCTASE GENE IN PATIENTS WITH RECURRENT ABORTION FROM THE IRANIAN AZERI TURKISH. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 4(3), 134-139. SID. https://sid.ir/paper/304715/en

Vancouver: Copy

BAGHERI MORTEZA, ABDIRAD I., OMRANI M.D., NAN BAKHSH F.. C677T AND A1298C MUTATIONS IN THE METHYLENETETRAHYDROFOLATE REDUCTASE GENE IN PATIENTS WITH RECURRENT ABORTION FROM THE IRANIAN AZERI TURKISH. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2010;4(3):134-139. Available from: https://sid.ir/paper/304715/en

IEEE: Copy

MORTEZA BAGHERI, I. ABDIRAD, M.D. OMRANI, and F. NAN BAKHSH, “C677T AND A1298C MUTATIONS IN THE METHYLENETETRAHYDROFOLATE REDUCTASE GENE IN PATIENTS WITH RECURRENT ABORTION FROM THE IRANIAN AZERI TURKISH,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 4, no. 3, pp. 134–139, 2010, [Online]. Available: https://sid.ir/paper/304715/en

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