CAN ALTERED EXPRESSION OF HSPA2 IN VARICOCELE PATIENTS LEAD TO ABNORMAL SPERMATOGENESIS?

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NASR ESFAHANI M.H.; ABBASI HOMAYOUN; MIRHOSSEINI ZAHRA; GHASEMI NAZEM; RAZAVI SHAHNAZ; TAVALAEI MARZIEH; TANHAEI S.; DEMEH M.R.; GHAEDI K.; ZAMAN SOLTANI F.; RAJAEI FARZAD

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Journal: International Journal of Fertility & Sterility Year:2010 | Volume:4 | Issue:3 Page(s): 104-113

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Title

CAN ALTERED EXPRESSION OF HSPA2 IN VARICOCELE PATIENTS LEAD TO ABNORMAL SPERMATOGENESIS?

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Keywords

VARICOCELE

HSPA2

PROTAMINES

DNA FRAGMENTATION

SURGERY

Abstract

Background: Heat shock protein A2 (HSPA2) is correlated with sperm maturity and function. Therefore, dysfunctional expression of this gene results in abnormal spermatogenesis. On the other hand, DNA damage in spermatozoa is considered to be an important cause of male infertility, and the presence of sperm with DNA FRAGMENTATION and chromatin abnormalities in human ejaculates is well documented, in particular in men with poor semen quality. Therefore, the aim of this study is to evaluate HSPA2 expression and its relation with DNA FRAGMENTATION, protamine deficiency involved in DNA packaging and semen parameters in VARICOCELE patients in comparison to fertile men before and after VARICOCELEctomy.Materials and Methods: This study included 52 fertile individuals as the control group and 70 infertile individuals with VARICOCELE as the experimental group. Sperm DNA FRAGMENTATION, protamine deficiency and relative HSPA2 expression were evaluated by the sperm chromatin dispersion test, chromomycin A3 staining and RT-PCR, respectively.Results: The mean values of abnormal morphology, protamine deficiency and DNA FRAGMENTATION were significantly lower in VARICOCELE individuals following VARICOCELEctomy when compared to fertile individuals. The correlation between these parameters were studied and discussed in the text. Conclusion: There is a decrease in relative HSPA2 expression which is possibly due to chronic induced hyperthermia in VARICOCELE individuals. Removal of this stress increases HSPA2 expression and results in the proper folding of proteins involved in spermatogenesis; therefore resulting in improved DNA packaging, as well as better sperm morphology and motility which may indirectly reduce sperm DNA FRAGMENTATION.

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APA: Copy

NASR ESFAHANI, M.H., ABBASI, HOMAYOUN, MIRHOSSEINI, ZAHRA, GHASEMI, NAZEM, RAZAVI, SHAHNAZ, TAVALAEI, MARZIEH, TANHAEI, S., DEMEH, M.R., GHAEDI, K., ZAMAN SOLTANI, F., & RAJAEI, FARZAD. (2010). CAN ALTERED EXPRESSION OF HSPA2 IN VARICOCELE PATIENTS LEAD TO ABNORMAL SPERMATOGENESIS?. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 4(3), 104-113. SID. https://sid.ir/paper/304717/en

Vancouver: Copy

NASR ESFAHANI M.H., ABBASI HOMAYOUN, MIRHOSSEINI ZAHRA, GHASEMI NAZEM, RAZAVI SHAHNAZ, TAVALAEI MARZIEH, TANHAEI S., DEMEH M.R., GHAEDI K., ZAMAN SOLTANI F., RAJAEI FARZAD. CAN ALTERED EXPRESSION OF HSPA2 IN VARICOCELE PATIENTS LEAD TO ABNORMAL SPERMATOGENESIS?. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2010;4(3):104-113. Available from: https://sid.ir/paper/304717/en

IEEE: Copy

M.H. NASR ESFAHANI, HOMAYOUN ABBASI, ZAHRA MIRHOSSEINI, NAZEM GHASEMI, SHAHNAZ RAZAVI, MARZIEH TAVALAEI, S. TANHAEI, M.R. DEMEH, K. GHAEDI, F. ZAMAN SOLTANI, and FARZAD RAJAEI, “CAN ALTERED EXPRESSION OF HSPA2 IN VARICOCELE PATIENTS LEAD TO ABNORMAL SPERMATOGENESIS?,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 4, no. 3, pp. 104–113, 2010, [Online]. Available: https://sid.ir/paper/304717/en

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