A COMPARATIVE STUDY OF THE EFFECT OF ANTIFUNGAL DRUGS (TERBINAFINE AND KETOCONAZOLE) ON MALASSEZIA FURFUR ISOLATES GROWTH IN VITRO

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SHAMS GHAHFAROKHI M.; SHOKOUH AMIRI M.R.; SADEGHI GOLNAR; RAZAGHI ABYANEH M.; MIRZAHOSSEINI H.

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Journal: DANESHVAR MEDICINE Year:2007 | Volume:14 | Issue:66 Page(s): 45-52

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Title

A COMPARATIVE STUDY OF THE EFFECT OF ANTIFUNGAL DRUGS (TERBINAFINE AND KETOCONAZOLE) ON MALASSEZIA FURFUR ISOLATES GROWTH IN VITRO

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Keywords

MALASSEZIA FURFURQ3

ANTIFUNGAL ACTIVITYQ3

TERBINAFINEQ3

KETOCONAZOLEQ3

AGAR DILUTION METHODQ3

Abstract

Introduction: Malassezia species are considered as etiological agents of superficial skin disorders, specially a chronic recurrent disease named tinea versicolor in addition, they cause systemic diseases associated with lipid-rich hyperalimentation fluids.Materials & Method: In this study, in vitro activities of two known antifungal drugs terbinatine (TBF) and KETOCONAZOLE (KTZ) were investigated for 25 MALASSEZIA FURFUR strains isolated from patients with tinea versicolor. AGAR DILUTION METHOD was used for determining the antifungal activities of forementioned compounds. The fungi were cultured on modified Dixon broth in the presence of different concentrations of drugs.Results: The minimal inhibitory concentrations (MICs) of TBF and KTZ were measured in the range of 1.53-24.5 (mg/ml) and 0.18-1.5 (mg/ml) for all tested M. furfur isolates, respectively. the MFC values of TBF and KTZ were assigned as 49-98 (mg/ml) and 3-12 (mg/ml), respectively. Overall KTZ showed suitable antifungal activities against all M. furfur tested in very low concentrations as compared to TBF.Conclusion: On the basis of the obtained results, evaluation of antifungal susceptibility for clinical Malassesia isolates before selection of antifungal drugs and onset of treatment is essential because of the differences observed in species and strain level. This may lead to better treatment and prevention by creating drug-resistant isolates which are non-responsive to routine antifungals.

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APA: Copy

SHAMS GHAHFAROKHI, M., SHOKOUH AMIRI, M.R., SADEGHI, GOLNAR, RAZAGHI ABYANEH, M., & MIRZAHOSSEINI, H.. (2007). A COMPARATIVE STUDY OF THE EFFECT OF ANTIFUNGAL DRUGS (TERBINAFINE AND KETOCONAZOLE) ON MALASSEZIA FURFUR ISOLATES GROWTH IN VITRO. DANESHVAR MEDICINE, 14(66), 45-52. SID. https://sid.ir/paper/30511/en

Vancouver: Copy

SHAMS GHAHFAROKHI M., SHOKOUH AMIRI M.R., SADEGHI GOLNAR, RAZAGHI ABYANEH M., MIRZAHOSSEINI H.. A COMPARATIVE STUDY OF THE EFFECT OF ANTIFUNGAL DRUGS (TERBINAFINE AND KETOCONAZOLE) ON MALASSEZIA FURFUR ISOLATES GROWTH IN VITRO. DANESHVAR MEDICINE[Internet]. 2007;14(66):45-52. Available from: https://sid.ir/paper/30511/en

IEEE: Copy

M. SHAMS GHAHFAROKHI, M.R. SHOKOUH AMIRI, GOLNAR SADEGHI, M. RAZAGHI ABYANEH, and H. MIRZAHOSSEINI, “A COMPARATIVE STUDY OF THE EFFECT OF ANTIFUNGAL DRUGS (TERBINAFINE AND KETOCONAZOLE) ON MALASSEZIA FURFUR ISOLATES GROWTH IN VITRO,” DANESHVAR MEDICINE, vol. 14, no. 66, pp. 45–52, 2007, [Online]. Available: https://sid.ir/paper/30511/en

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