STUI POLYMORPHISM ON THE ANDROGEN RECEPTOR GENE IN WOMEN WITH ENDOMETRIOSIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JAHANINEJAD T.; GHASEMI N.; ZAIMY M.A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Fertility & Sterility Year:2012 | Volume:6 | Issue:SUPPLEMENT 1 Page(s): 123-123

Download Full-Text

View:

297

Download:

Cites:

Information Journal Paper

Title

STUI POLYMORPHISM ON THE ANDROGEN RECEPTOR GENE IN WOMEN WITH ENDOMETRIOSIS

Author(s)

JAHANINEJAD T. | GHASEMI N. | ZAIMY M.A.

Keywords

ENDOMETRIOSIS

ANDROGEN RECEPTOR

Abstract

Background: Androgens have an anti-proliferative effect on endometrial cells. Human ANDROGEN RECEPTOR (AR) gene contains two polymorphic short tandem repeats of GGC and CAG, and a single-nucleotide polymorphism on exon 1 that is recognized by the restriction enzyme, StuI. Prior studies have shown that the lengths of the CAG and GGC repeats are inversely and linearly related to AR activity and associated with ENDOMETRIOSIS and endometrial cancer. However, little is known about the single nucleotide polymorphism of the AR gene.Thus, we investigated whether these AR polymorphisms are risk factors for ENDOMETRIOSIS.Materials and Methods: The genetic distributions of these polymorphisms were investigated in blood samples from 100 ENDOMETRIOSIS patients and healthy controls.The allelic profiles were analyzed by polymerase chain reaction (PCR), PCR-restriction fragment length polymorphism (PCR-RFLP) and analyzed statistically.Results: The observed frequencies of GG, GA and AA genotypes of the G1733A polymorphism were 0.14, 0.68 and 0.18, respectively, for the patient group and 0.68, 0.3, and 0.02, respectively, for the control group. Allele frequencies were 0.48 and 0.83, respectively, for the patient and control groups for the G allele (wild type) and 0.52 and 0.17, respectively, for the patient and control groups for the A allele (mutant). Statistical analysis of these results indicated significant differences between the two groups (p=0.00014).Conclusion: These results indicated for the first time that the ANDROGEN RECEPTOR G1733A polymorphism is strongly associated with increased risk for ENDOMETRIOSIS.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

JAHANINEJAD, T., GHASEMI, N., & ZAIMY, M.A.. (2012). STUI POLYMORPHISM ON THE ANDROGEN RECEPTOR GENE IN WOMEN WITH ENDOMETRIOSIS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 6(SUPPLEMENT 1), 123-123. SID. https://sid.ir/paper/305302/en

Vancouver: Copy

JAHANINEJAD T., GHASEMI N., ZAIMY M.A.. STUI POLYMORPHISM ON THE ANDROGEN RECEPTOR GENE IN WOMEN WITH ENDOMETRIOSIS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2012;6(SUPPLEMENT 1):123-123. Available from: https://sid.ir/paper/305302/en

IEEE: Copy

T. JAHANINEJAD, N. GHASEMI, and M.A. ZAIMY, “STUI POLYMORPHISM ON THE ANDROGEN RECEPTOR GENE IN WOMEN WITH ENDOMETRIOSIS,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 6, no. SUPPLEMENT 1, pp. 123–123, 2012, [Online]. Available: https://sid.ir/paper/305302/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops